Interleukin-1 Gene Complex in Schizophrenia: An Association Study

The aim of this study is to investigate the association between three polymorphisms of the interleukin‐1 (IL‐1) gene complex and schizophrenia. We genotyped 228 outpatients with schizophrenia (DSM‐IV criteria) and 419 unrelated healthy controls. The following polymorphisms were analyzed: IL‐1α −889...

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Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2006-09, Vol.141B (6), p.678-680
Main Authors: Saiz, Pilar A., Garcia-Portilla, Maria P., Arango, Celso, Morales, Blanca, Martinez-Barrondo, Sara, Alvarez, Victoria, Coto, Eliecer, Fernandez, Juan, Bousono, Manuel, Bobes, Julio
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alleles
Biological and medical sciences
Gene Frequency
genetic association
Humans
Interleukin-1 - genetics
interleukin-1 gene complex
Medical sciences
polymorphisms
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - genetics
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Summary:The aim of this study is to investigate the association between three polymorphisms of the interleukin‐1 (IL‐1) gene complex and schizophrenia. We genotyped 228 outpatients with schizophrenia (DSM‐IV criteria) and 419 unrelated healthy controls. The following polymorphisms were analyzed: IL‐1α −889 C/T, IL‐1β +3953 C/T, and IL‐1RA (86 bp)n. No significant differences in genotype or in allelic distribution of the Il‐1α, IL‐1β, and IL‐1RA polymorphisms were found. Estimated haplotype frequencies were similar in both groups. Our data do not suggest that genetically determined changes in the IL‐1 gene complex confer increased susceptibility for schizophrenia. © 2005 Wiley‐Liss, Inc.
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30394