Correlation and prognostic utility of B-type natriuretic peptide and its amino-terminal fragment in patients with chronic kidney disease

This study compared the correlation and prognostic utility of B-type natriuretic peptide (BNP) and the N-terminal fragment of proBNP (NT-proBNP) in 171 outpatients with renal dysfunction. The NT-proBNP correlated well with BNP in all cases (r = 0.911; P pound .01), regardless of degree of renal impa...

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Published in:American journal of clinical pathology 2006-10, Vol.126 (4), p.506-512
Main Authors: AUSTIN, Wendy J, BHALLA, Vikas, HERNANDEZ-ARCE, Israel, ISAKSON, Susan R, BEEDE, Jennifer, CLOPTON, Paul, MAISEL, Alan S, FITZGERALD, Robert L
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
Chronic Disease
Female
Hospitalization - statistics & numerical data
Humans
Investigative techniques, diagnostic techniques (general aspects)
Kidney Diseases - blood
Kidney Diseases - complications
Kidney Diseases - diagnosis
Kidney Diseases - mortality
Kidneys
Male
Medical sciences
Natriuretic Peptide, Brain - blood
Nephrology. Urinary tract diseases
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Peptide Fragments - blood
Prognosis
Prospective Studies
Protein Precursors - blood
Survival Rate
Urinary system involvement in other diseases. Miscellaneous
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - mortality
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Summary:This study compared the correlation and prognostic utility of B-type natriuretic peptide (BNP) and the N-terminal fragment of proBNP (NT-proBNP) in 171 outpatients with renal dysfunction. The NT-proBNP correlated well with BNP in all cases (r = 0.911; P pound .01), regardless of degree of renal impairment or type of left ventricular dysfunction. BNP and NT-proBNP concentrations (P < .005) and their ratios (P pound .01) increased as the glomerular filtration rate (GFR) declined, indicating a greater effect of GFR on NT-proBNP levels. Both natriuretic peptide levels were higher in patients with systolic dysfunction (P < .05) compared with patients with normal echocardiograms. In contrast, BNP and NT-proBNP levels were below the diagnostic cutoffs for congestive heart failure exacerbations in patients with normal heart function or diastolic dysfunction, with no statistical difference between these groups (P = .99). Both peptides are useful prognostic tools for predicting mortality and cardiac hospitalization in renal patients.
ISSN:0002-9173
1943-7722
DOI:10.1309/M7AAXA0J1THMNCDF