Combining Enabling Techniques in Organic Synthesis: Continuous Flow Processes with Heterogenized Catalysts

The concepts article describes enabling techniques (solid‐phase assisted synthesis, new reactor design, microwave irradiation and new solvents) in organic chemistry and emphasizes the combination of several of them for creating new synthetic technology platforms. Particular focus is put on the combi...

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Bibliographic Details
Published in:Chemistry : a European journal 2006-08, Vol.12 (23), p.5972-5990
Main Authors: Kirschning, Andreas, Solodenko, Wladimir, Mennecke, Klaas
Format: Article
Language:English
Subjects:
CC coupling
heterogeneous catalysis
immobilization
microreactors
organic chemistry
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Summary:The concepts article describes enabling techniques (solid‐phase assisted synthesis, new reactor design, microwave irradiation and new solvents) in organic chemistry and emphasizes the combination of several of them for creating new synthetic technology platforms. Particular focus is put on the combination of immobilized catalysts as well as biocatalysts with continuous flow processes. In this context, the PASSflow continuous flow technique fulfils both chemical as well as chemical engineering requirements. It combines reactor design with optimized, monolithic solid phases as well as reversible immobilization techniques for performing small as well as large scale synthesis with heterogenized catalysts under continuous flow conditions. Ready, able and willing: Enabling techniques (that is, solid‐phase assisted synthesis, new reactor design, microwave irradiation, and new solvents) can be used in various combinations for new synthetic technology platforms.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200600236