Improved fibrinolysis by an intensive lifestyle intervention in subjects with impaired glucose tolerance. The Finnish Diabetes Prevention Study

• Published in: Diabetologia 2005-11, Vol.48 (11), p.2248-2253
• Main Authors: HÄMÄLÄINEN, H, RÖNNEMAA, T, UUSITUPA, M, TUOMILEHTO, J, VIRTANEN, A, LINDSTRÖM, J, ERIKSSON, J. G, VALLE, T. T, ILANNE-PARIKKA, P, KEINÄNEN-KIUKAANNIEMI, S, RASTAS, M, AUNOLA, S
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Cardiovascular disease; Diabetes; Diabetes Mellitus - prevention & control; Diabetes Mellitus, Type 2 - prevention & control; Diabetes. Impaired glucose tolerance; Diet; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exercise; Female; Fibrinogen - metabolism; Fibrinolysis; Finland; Follow-Up Studies; Glucose; Glucose Intolerance - metabolism; Health care; Humans; Life Style; Lifestyles; Male; Medical sciences; Middle Aged; Nutrition research; Physical fitness; Plasminogen Activator Inhibitor 1 - blood; Prevention; Public health; Weight Loss
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-005-1938-5

The aim of this study was to investigate the effects of lifestyle intervention on the levels of plasminogen activator inhibitor (PAI-1) and fibrinogen in subjects participating in the Finnish Diabetes Prevention Study (DPS). In five DPS centres, 321 subjects with impaired glucose tolerance (intervention group, n=163; control group, n=158) had their PAI-1 and fibrinogen levels measured at baseline and at the 1-year follow-up. Additional 3-year follow-up assessments were carried out in a sample of 97 subjects in one of the DPS centres (Turku). The intervention programme included an intensive lifestyle intervention aiming at weight reduction, healthy diet and increased physical activity. During the first intervention year, PAI-1 decreased by 31% in the intervention group but showed no change in the control group (p