Stage-dependent BDNF serum concentrations in Alzheimer's disease

Alzheimer's disease (AD) is characterized by cognitive decline and loss of neurons in specific brain regions. Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. BDNF is an endogenous protein involved in the maintenance of neurona...

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Bibliographic Details
Published in:Journal of Neural Transmission 2006-09, Vol.113 (9), p.1217-1224
Main Authors: Laske, C, Stransky, E, Leyhe, T, Eschweiler, G W, Wittorf, A, Richartz, E, Bartels, M, Buchkremer, G, Schott, K
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - blood
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - psychology
Alzheimer's disease
Brain-Derived Neurotrophic Factor - blood
Brain-Derived Neurotrophic Factor - cerebrospinal fluid
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Neuropsychological Tests
Pilot Projects
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Summary:Alzheimer's disease (AD) is characterized by cognitive decline and loss of neurons in specific brain regions. Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic plasticity and structural integrity in the adult brain. To our knowledge, the present pilot study assessed for the first time BDNF serum and CSF concentrations in 30 patients with different stages of AD in comparison to 10 age-matched non-demendet controls. AD patients were divided in two groups according to their MMSE score: Group 1 (n = 15) in early stages with MMSE scores >or=21 (mean of 25.5) and Group 2 (n = 15) with more severe stages of dementia with MMSE scores
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-005-0397-y