Human, rhesus macaque, and feline sequences highly similar to mouse mammary tumor virus sequences

Sequences highly similar (>95%) to the mouse mammary tumor virus (MMTV) env gene have been amplified from human DNA samples, including DNA samples from patients with breast cancer (BC) and persons who did not have BC. The sequences from human DNA were distinct from the MMTV sequences used as cont...

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Bibliographic Details
Published in:Microscopy research and technique 2005-11, Vol.68 (3-4), p.209-221
Main Authors: Szabo, Sara, Haislip, Allyson M., Traina-Dorge, Vicki, Costin, Joshua M., Crawford II, Byron E., Wilson, Russell B., Garry, Robert F.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
breast cancer
Breast Neoplasms - virology
Cats
DNA, Neoplasm - analysis
DNA, Viral - analysis
Echinoidea
feline
Female
Genes, env
Humans
Macaca mulatta
Mammary Tumor Virus, Mouse - genetics
Molecular Sequence Data
monkey
Mouse mammary tumor virus
mouse mammary tumor virus (MMTV)
Polymerase Chain Reaction
rodent
Sequence Analysis, DNA
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Summary:Sequences highly similar (>95%) to the mouse mammary tumor virus (MMTV) env gene have been amplified from human DNA samples, including DNA samples from patients with breast cancer (BC) and persons who did not have BC. The sequences from human DNA were distinct from the MMTV sequences used as controls in these PCR reactions, indicating that these results are not simply due to contamination. In addition to both, mouse and human‐related sequences were also amplified from some monkey and cat genomic DNA samples. These products were shown to be distinct from, but highly related to, the MMTV env gene, whereas, testing of other sources (lambda phage, snake, cockroach, sea urchin, chicken, or dog) demonstrated no specific amplification. A sequence ˜90% similar to the MMTV group antigen gene (gag) was amplified from cat DNA. These results indicate that DNA from vertebrate species other than rodents, including some but not all humans, monkeys, and cats, can contain sequences closely related to MMTV. Microsc. Res. Tech. 68:209–221, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:1059-910X
1097-0029
DOI:10.1002/jemt.20233