Integrated Microfluidics for Parallel Screening of an In Situ Click Chemistry Library

State‐of‐the‐art: Automated chemical reaction circuits have been demonstrated to serve as a miniaturized operation platform for the parallel screening of 32 in situ click chemistry reactions with reduced consumption of reagents. A proof‐of‐concept study was performed with the bovine carbonic anhydra...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-08, Vol.45 (32), p.5276-5281
Main Authors: Wang, Jinyi, Sui, Guodong, Mocharla, Vani P., Lin, Rachel J., Phelps, Michael E., Kolb, Hartmuth C., Tseng, Hsian-Rong
Format: Article
Language:English
Subjects:
click chemistry
Combinatorial Chemistry Techniques - instrumentation
Combinatorial Chemistry Techniques - methods
enzyme catalysis
high-throughput screening
Ligands
Microfluidics - instrumentation
microreactors
Molecular Structure
parallel synthesis
Proteins - chemistry
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Summary:State‐of‐the‐art: Automated chemical reaction circuits have been demonstrated to serve as a miniaturized operation platform for the parallel screening of 32 in situ click chemistry reactions with reduced consumption of reagents. A proof‐of‐concept study was performed with the bovine carbonic anhydrase II (bCAII) click chemistry system.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200601677