A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents

A one-step, mild procedure based on coaxial electrospinning was developed for incorporation and controlled release of two model proteins, BSA and lysozyme, from biodegradable core-shell nanofibers with PCL as shell and protein-containing PEG as core. The thickness of the core and shell could be adju...

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Bibliographic Details
Published in:Journal of controlled release 2005-11, Vol.108 (2-3), p.237-243
Main Authors: Jiang, Hongliang, Hu, Yingqian, Li, Yan, Zhao, Pengcheng, Zhu, Kangjie, Chen, Weiliam
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chemistry, Pharmaceutical
Controlled release
Core-shell
Delayed-Action Preparations - chemical synthesis
Drug Compounding
Electrophoresis, Polyacrylamide Gel
Electrospinning
Excipients
General pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Microscopy, Electron, Transmission
Muramidase - administration & dosage
Muramidase - chemistry
Nanostructures
Ovalbumin - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyesters
Polyethylene Glycols
Proteins - administration & dosage
Proteins - chemistry
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Summary:A one-step, mild procedure based on coaxial electrospinning was developed for incorporation and controlled release of two model proteins, BSA and lysozyme, from biodegradable core-shell nanofibers with PCL as shell and protein-containing PEG as core. The thickness of the core and shell could be adjusted by the feed rate of the inner dope, which in turn affected the release profiles of the incorporated proteins. It was revealed that the released lysozyme maintained its structure and bioactivity. The current method may find wide applications for controlled release of proteins and tissue engineering.
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2005.08.006