Drosophila as a model for human neurodegenerative disease

Among many achievements in the neurodegeneration field in the past decade, two require special attention due to the huge impact on our understanding of molecular and cellular pathogenesis of human neurodegenerative diseases. First is defining specific mutations in familial neurodegenerative diseases...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of genetics 2005-01, Vol.39 (1), p.153-171
Main Authors: Bilen, Julide, Bonini, Nancy M
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Alzheimer Disease - physiopathology
Animals
Disease Models, Animal
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Fruits
Gene expression
Genetic engineering
Genetic factors
Humans
Insects
Nematoda
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - physiopathology
Neurological disorders
Parkinson Disease - genetics
Parkinson Disease - physiopathology
Risk factors
Trinucleotide Repeats - genetics
Trinucleotide Repeats - physiology
Yeasts
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Among many achievements in the neurodegeneration field in the past decade, two require special attention due to the huge impact on our understanding of molecular and cellular pathogenesis of human neurodegenerative diseases. First is defining specific mutations in familial neurodegenerative diseases and second is modeling these diseases in easily manipulable model organisms including the fruit fly, nematode, and yeast. The power of these genetic systems has revealed many genetic factors involved in the various pathways affected, as well as provided potential drug targets for therapeutics. This review focuses on fruit fly models of human neurodegenerative diseases, with emphasis on how fly models have provided new insights into various aspects of human diseases.
ISSN:0066-4197
1545-2948
DOI:10.1146/annurev.genet.39.110304.095804