Amphiphile-induced tubular budding of the bilayer membrane

Amphiphile-induced tubular budding of the erythrocyte membrane was studied using transmission electron microscopy. No chiral patterns of the intramembraneous particles were found, either on the cylindrical buds, or on the tubular nanoexovesicles. In agreement with these observations, the tubular bud...

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Bibliographic Details
Published in:European biophysics journal 2005-11, Vol.34 (8), p.1066-1070
Main Authors: Kralj-Iglic, Veronika, Hägerstrand, Henry, Veranic, Peter, Jezernik, Kristijan, Babnik, Blaz, Gauger, Dorit R, Iglic, Ales
Format: Article
Language:English
Subjects:
Cell Size
Cells, Cultured
Computer Simulation
Electrons
Erythrocyte Membrane - chemistry
Erythrocyte Membrane - physiology
Erythrocyte Membrane - ultrastructure
Humans
Lipid Bilayers - chemistry
Membrane Fluidity
Membranes
Models, Cardiovascular
Models, Chemical
Molecular Conformation
Surface-Active Agents - chemistry
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Summary:Amphiphile-induced tubular budding of the erythrocyte membrane was studied using transmission electron microscopy. No chiral patterns of the intramembraneous particles were found, either on the cylindrical buds, or on the tubular nanoexovesicles. In agreement with these observations, the tubular budding may be explained by in-plane ordering of anisotropic membrane inclusions in the buds where the difference between the principal membrane curvatures is very large. In contrast to previously reported theories, no direct external mechanical force is needed to explain tubular budding of the bilayer membrane.
ISSN:0175-7571
1432-1017
DOI:10.1007/s00249-005-0481-0