Candida dubliniensis: Ten years on

Candida dubliniensis was first described as a novel species in 1995. This organism is very closely related to the important human yeast pathogen, Candida albicans. However, despite the very close phylogenetic relationship between C. albicans and C. dubliniensis and the fact that they share a large n...

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Bibliographic Details
Published in:FEMS microbiology letters 2005-12, Vol.253 (1), p.9-17
Main Authors: Sullivan, Derek J., Moran, Gary P., Coleman, David C.
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
Biological evolution
Candida - drug effects
Candida - genetics
Candida - pathogenicity
Candida albicans
Candida albicans - genetics
Candida albicans - pathogenicity
Candida dubliniensis
Candidiasis - microbiology
Divergence
Drug Resistance, Fungal - genetics
Epidemiology
Fundamental and applied biological sciences. Psychology
Gene sequencing
Genetics
Genome, Fungal
Genomes
Genomics
Humans
Hybridization
Microbiology
Molecular Epidemiology
Pathogenesis
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Phenotype
Phylogeny
Species
Species Specificity
Systematics
Virulence
Virulence - genetics
Yeast
Yeasts
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Description
Summary:Candida dubliniensis was first described as a novel species in 1995. This organism is very closely related to the important human yeast pathogen, Candida albicans. However, despite the very close phylogenetic relationship between C. albicans and C. dubliniensis and the fact that they share a large number of phenotypic traits, epidemiological and virulence model data indicate that the former is a far more successful pathogen. In order to investigate the molecular basis of the lower virulence of C. dubliniensis recent comparative genomic hybridisation studies have revealed the absence and divergence of specific genes implicated in candidal virulence. Data from the C. dubliniensis genome sequencing project will allow a complete comparison between the genomes of the two species to be performed and thus enhance our understanding of candidal virulence and how virulence has evolved in Candida species.
ISSN:0378-1097
1574-6968
DOI:10.1016/j.femsle.2005.09.015