Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides

Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective “fusion” of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society 2005-11, Vol.127 (46), p.15998-15999
Main Authors: Zhang, Li, Chen, Xinguo, Xue, Peng, Sun, Herman H. Y, Williams, Ian D, Sharpless, K. Barry, Fokin, Valery V, Jia, Guochen
Format: Article
Language:English
Subjects:
Acetylene - analogs & derivatives
Acetylene - chemistry
Alkynes - chemistry
Azides - chemistry
Catalysis
Chemical reactivity
Chemistry
Exact sciences and technology
Molecular Structure
Organic chemistry
Reactivity and mechanisms
Ruthenium - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective “fusion” of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this catalysis, resulting in fully substituted 1,2,3-triazoles.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja054114s