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Influence of cardiac output level on oxygen exchange in chronic obstructive pulmonary disease patients
Summary Study objectives: In the course of chronic obstructive pulmonary disease (COPD), pulmonary gas exchange deteriorates as a result of ventilation/perfusion inequalities and hypoxaemia. The aim of the present study was to evaluate the influence of cardiac output (CO) level observed at rest in...
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| Published in: | Clinical physiology and functional imaging 2006-09, Vol.26 (5), p.275-282 |
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| container_issue | 5 |
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| container_title | Clinical physiology and functional imaging |
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| creator | Manier, Gérard Pillet, Odile Castaing, Yves |
| description | Summary
Study objectives: In the course of chronic obstructive pulmonary disease (COPD), pulmonary gas exchange deteriorates as a result of ventilation/perfusion inequalities and hypoxaemia. The aim of the present study was to evaluate the influence of cardiac output (CO) level observed at rest in COPD patients on interaction between central and peripheral O2 exchange.
Methods: One hundred and nine patients with advanced but stable COPD were analysed in a retrospective study by the multiple inert gas elimination technique. As a function of CO, simulations were conducted to evaluate the respective part of PvO2 and inequalities on the degree of hypoxaemia.
Measurements and results: PaO2 was linked (i) to cardiac index (CI), (ii) to mean ratio of blood flow distribution and (iii) to PvO2, but PvO2 was not correlated with CO. By comparing two groups with CI above and below the mean value of the series respectively, a significant difference was identified in PaO2 (57 ± 9 mmHg in the high CI group versus 63 ± 10 mmHg in the low CI group, P |
| doi_str_mv | 10.1111/j.1475-097X.2006.00687.x |
| format | article |
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Study objectives: In the course of chronic obstructive pulmonary disease (COPD), pulmonary gas exchange deteriorates as a result of ventilation/perfusion inequalities and hypoxaemia. The aim of the present study was to evaluate the influence of cardiac output (CO) level observed at rest in COPD patients on interaction between central and peripheral O2 exchange.
Methods: One hundred and nine patients with advanced but stable COPD were analysed in a retrospective study by the multiple inert gas elimination technique. As a function of CO, simulations were conducted to evaluate the respective part of PvO2 and inequalities on the degree of hypoxaemia.
Measurements and results: PaO2 was linked (i) to cardiac index (CI), (ii) to mean ratio of blood flow distribution and (iii) to PvO2, but PvO2 was not correlated with CO. By comparing two groups with CI above and below the mean value of the series respectively, a significant difference was identified in PaO2 (57 ± 9 mmHg in the high CI group versus 63 ± 10 mmHg in the low CI group, P<0·05) because of higher inequalities in the high CI group. Comparing two other groups with values of PvO2 above and below the mean value of the series respectively, a significant difference was identified in PaO2: (mean ± SD was 65 ± 8 in high PvO2 group versus 56 ± 9 mmHg, P<0·001) but with no difference in either CI or perfusion distribution. Analysis of the cumulated effects of PvO2 and CI values, indicated that high CI and low PvO2 gave rise to the lowest PaO2 (53 ± 8 mmHg), with the highest PaO2 (68 ± 8 mmHg) being found in the low CI and normal PvO2 group.
Conclusions: We concluded that in COPD patients, PaO2 appeared to be maintained better when peripheral gas exchange coped with tissue demand without an increase in CO. Conversely, when the physiological increase in CO could not maintain adequate tissue gas exchange, PaO2 continued to fall due to the cumulative effects of increasing CO on inequalities and low PvO2.</description><identifier>ISSN: 1475-0961</identifier><identifier>EISSN: 1475-097X</identifier><identifier>DOI: 10.1111/j.1475-097X.2006.00687.x</identifier><identifier>PMID: 16939504</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cardiac Output ; chronic obstructive pulmonary disease ; Female ; Fundamental and applied biological sciences. Psychology ; gas exchange ; Humans ; Hypoxia ; Male ; Middle Aged ; Models, Theoretical ; multiple inert gas elimination technique ; Myocardium - metabolism ; Oxygen - metabolism ; Oxygen Inhalation Therapy ; Pulmonary Disease, Chronic Obstructive - therapy ; Pulmonary Gas Exchange ; Retrospective Studies ; tissue oxygenation ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Clinical physiology and functional imaging, 2006-09, Vol.26 (5), p.275-282</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3797-feb747b797b984b97d1abb98c3a7a925726f7f315b13d4e45a59289f45dff07b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18049209$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16939504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manier, Gérard</creatorcontrib><creatorcontrib>Pillet, Odile</creatorcontrib><creatorcontrib>Castaing, Yves</creatorcontrib><title>Influence of cardiac output level on oxygen exchange in chronic obstructive pulmonary disease patients</title><title>Clinical physiology and functional imaging</title><addtitle>Clin Physiol Funct Imaging</addtitle><description>Summary
Study objectives: In the course of chronic obstructive pulmonary disease (COPD), pulmonary gas exchange deteriorates as a result of ventilation/perfusion inequalities and hypoxaemia. The aim of the present study was to evaluate the influence of cardiac output (CO) level observed at rest in COPD patients on interaction between central and peripheral O2 exchange.
Methods: One hundred and nine patients with advanced but stable COPD were analysed in a retrospective study by the multiple inert gas elimination technique. As a function of CO, simulations were conducted to evaluate the respective part of PvO2 and inequalities on the degree of hypoxaemia.
Measurements and results: PaO2 was linked (i) to cardiac index (CI), (ii) to mean ratio of blood flow distribution and (iii) to PvO2, but PvO2 was not correlated with CO. By comparing two groups with CI above and below the mean value of the series respectively, a significant difference was identified in PaO2 (57 ± 9 mmHg in the high CI group versus 63 ± 10 mmHg in the low CI group, P<0·05) because of higher inequalities in the high CI group. Comparing two other groups with values of PvO2 above and below the mean value of the series respectively, a significant difference was identified in PaO2: (mean ± SD was 65 ± 8 in high PvO2 group versus 56 ± 9 mmHg, P<0·001) but with no difference in either CI or perfusion distribution. Analysis of the cumulated effects of PvO2 and CI values, indicated that high CI and low PvO2 gave rise to the lowest PaO2 (53 ± 8 mmHg), with the highest PaO2 (68 ± 8 mmHg) being found in the low CI and normal PvO2 group.
Conclusions: We concluded that in COPD patients, PaO2 appeared to be maintained better when peripheral gas exchange coped with tissue demand without an increase in CO. Conversely, when the physiological increase in CO could not maintain adequate tissue gas exchange, PaO2 continued to fall due to the cumulative effects of increasing CO on inequalities and low PvO2.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiac Output</subject><subject>chronic obstructive pulmonary disease</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gas exchange</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Theoretical</subject><subject>multiple inert gas elimination technique</subject><subject>Myocardium - metabolism</subject><subject>Oxygen - metabolism</subject><subject>Oxygen Inhalation Therapy</subject><subject>Pulmonary Disease, Chronic Obstructive - therapy</subject><subject>Pulmonary Gas Exchange</subject><subject>Retrospective Studies</subject><subject>tissue oxygenation</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1475-0961</issn><issn>1475-097X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkE9vFCEchonR2Fr9CoaL3mYKM8wwJF7Mxq5N658YTb0RYH60rCyzhZk6--3LupvtVRLCG3geIC9CmJKS5nG-KinjTUEE_11WhLRlnh0v52fo9Hjw_JhbeoJepbQihPKa8ZfohLaiFg1hp8heBusnCAbwYLFRsXfK4GEaN9OIPTyAx0PAw7y9hYBhNncq3AJ2AZu7OASXUZ3GOJnRPQDeTH49BBW3uHcJVMo7anQQxvQavbDKJ3hzWM_Qr4tPPxefi-tvy8vFx-vC1FzwwoLmjOscteiYFrynSudoasWVqBpetZbbmjaa1j0D1qhGVJ2wrOmtJVzXZ-j9_t5NHO4nSKNcu2TAexVgmJJsu460pG0y2O1BE4eUIli5iW6dvy4pkbuO5Uru6pO7KuWuY_mvYzln9e3hjUmvoX8SD6Vm4N0BUMkob6MKxqUnriNMVERk7sOe--s8bP_7A3Lx_SKHrBd73aUR5qOu4h_Z8jqbN1-Xkn65WZKrH0t5VT8Ce1eo4w</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Manier, Gérard</creator><creator>Pillet, Odile</creator><creator>Castaing, Yves</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Influence of cardiac output level on oxygen exchange in chronic obstructive pulmonary disease patients</title><author>Manier, Gérard ; Pillet, Odile ; Castaing, Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3797-feb747b797b984b97d1abb98c3a7a925726f7f315b13d4e45a59289f45dff07b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiac Output</topic><topic>chronic obstructive pulmonary disease</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gas exchange</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Theoretical</topic><topic>multiple inert gas elimination technique</topic><topic>Myocardium - metabolism</topic><topic>Oxygen - metabolism</topic><topic>Oxygen Inhalation Therapy</topic><topic>Pulmonary Disease, Chronic Obstructive - therapy</topic><topic>Pulmonary Gas Exchange</topic><topic>Retrospective Studies</topic><topic>tissue oxygenation</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manier, Gérard</creatorcontrib><creatorcontrib>Pillet, Odile</creatorcontrib><creatorcontrib>Castaing, Yves</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical physiology and functional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manier, Gérard</au><au>Pillet, Odile</au><au>Castaing, Yves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of cardiac output level on oxygen exchange in chronic obstructive pulmonary disease patients</atitle><jtitle>Clinical physiology and functional imaging</jtitle><addtitle>Clin Physiol Funct Imaging</addtitle><date>2006-09</date><risdate>2006</risdate><volume>26</volume><issue>5</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>1475-0961</issn><eissn>1475-097X</eissn><abstract>Summary
Study objectives: In the course of chronic obstructive pulmonary disease (COPD), pulmonary gas exchange deteriorates as a result of ventilation/perfusion inequalities and hypoxaemia. The aim of the present study was to evaluate the influence of cardiac output (CO) level observed at rest in COPD patients on interaction between central and peripheral O2 exchange.
Methods: One hundred and nine patients with advanced but stable COPD were analysed in a retrospective study by the multiple inert gas elimination technique. As a function of CO, simulations were conducted to evaluate the respective part of PvO2 and inequalities on the degree of hypoxaemia.
Measurements and results: PaO2 was linked (i) to cardiac index (CI), (ii) to mean ratio of blood flow distribution and (iii) to PvO2, but PvO2 was not correlated with CO. By comparing two groups with CI above and below the mean value of the series respectively, a significant difference was identified in PaO2 (57 ± 9 mmHg in the high CI group versus 63 ± 10 mmHg in the low CI group, P<0·05) because of higher inequalities in the high CI group. Comparing two other groups with values of PvO2 above and below the mean value of the series respectively, a significant difference was identified in PaO2: (mean ± SD was 65 ± 8 in high PvO2 group versus 56 ± 9 mmHg, P<0·001) but with no difference in either CI or perfusion distribution. Analysis of the cumulated effects of PvO2 and CI values, indicated that high CI and low PvO2 gave rise to the lowest PaO2 (53 ± 8 mmHg), with the highest PaO2 (68 ± 8 mmHg) being found in the low CI and normal PvO2 group.
Conclusions: We concluded that in COPD patients, PaO2 appeared to be maintained better when peripheral gas exchange coped with tissue demand without an increase in CO. Conversely, when the physiological increase in CO could not maintain adequate tissue gas exchange, PaO2 continued to fall due to the cumulative effects of increasing CO on inequalities and low PvO2.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16939504</pmid><doi>10.1111/j.1475-097X.2006.00687.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Cardiac Output chronic obstructive pulmonary disease Female Fundamental and applied biological sciences. Psychology gas exchange Humans Hypoxia Male Middle Aged Models, Theoretical multiple inert gas elimination technique Myocardium - metabolism Oxygen - metabolism Oxygen Inhalation Therapy Pulmonary Disease, Chronic Obstructive - therapy Pulmonary Gas Exchange Retrospective Studies tissue oxygenation Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Influence of cardiac output level on oxygen exchange in chronic obstructive pulmonary disease patients |
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