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High-Risk Types of Human Papillomavirus (HPV) DNA in Oral and Genital Mucosa of Infants during Their First 3 Years of Life: Experience from the Finnish HPV Family Study
Background. This study is aimed to clarify data on the acquisition, persistence, and clearance of high-risk types of human papillomavirus (HPV) DNA from the mucosa and the determinants of persistent mucosal HPV infection in infants. Methods. Oral and genital scrapings from 324 infants were collected...
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Published in: | Clinical infectious diseases 2005-12, Vol.41 (12), p.1728-1733 |
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description | Background. This study is aimed to clarify data on the acquisition, persistence, and clearance of high-risk types of human papillomavirus (HPV) DNA from the mucosa and the determinants of persistent mucosal HPV infection in infants. Methods. Oral and genital scrapings from 324 infants were collected at birth, 3 days after delivery, and 1, 2, 6, 12, 24, and 36 months after delivery and tested for the presence of HPV DNA by nested polymerase chain reaction and hybridization with 12 high-risk HPV oligoprobes. HPV status and demographic data for parents were analyzed. Results. During the follow-up period (median duration, 26.2 months), HPV DNA was found to be present in 12%–21% of oral scrape samples and in 4%–15% of genital scrape samples obtained from the infants. Oral HPV infection was acquired by 42% of children, cleared by 11%, and persisted in 10% of the infants, whereas 37% were never infected. The corresponding figures for genital HPV infection were 36%, 14%, 1.5%, and 47%. Kaplan-Meier analysis revealed that both the cumulative incidence of infection and clearance of HPV were parallel in oral and genital sites. Persistent oral HPV infection in the child was significantly associated with persistent oral HPV infection in the mother at month 36 of follow-up, hand warts in the mother, young age at onset of sexual activity for the mother, and the mother's use of oral contraception, as well as with the father's oral HPV status at 24 months. Persistent genital HPV infection in the infant was predicted by if the mother had started smoking at 18–21 years of age and by a history of genital warts. Conclusions. Persistent carriage of high-risk HPV types was detected in oral and genital mucosa specimens obtained from 10% and 1.5% of the infants during their first 26 months of life. The rates of acquisition and clearance of HPV were similar in oral and genital mucosa. |
doi_str_mv | 10.1086/498114 |
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M. ; Grénman, Seija E. ; Järvenkylä, Marja E. ; Syrjänen, Kari J. ; Syrjänen, Stina M.</creator><creatorcontrib>Rintala, Marjut A. M. ; Grénman, Seija E. ; Järvenkylä, Marja E. ; Syrjänen, Kari J. ; Syrjänen, Stina M.</creatorcontrib><description>Background. This study is aimed to clarify data on the acquisition, persistence, and clearance of high-risk types of human papillomavirus (HPV) DNA from the mucosa and the determinants of persistent mucosal HPV infection in infants. Methods. Oral and genital scrapings from 324 infants were collected at birth, 3 days after delivery, and 1, 2, 6, 12, 24, and 36 months after delivery and tested for the presence of HPV DNA by nested polymerase chain reaction and hybridization with 12 high-risk HPV oligoprobes. HPV status and demographic data for parents were analyzed. Results. During the follow-up period (median duration, 26.2 months), HPV DNA was found to be present in 12%–21% of oral scrape samples and in 4%–15% of genital scrape samples obtained from the infants. Oral HPV infection was acquired by 42% of children, cleared by 11%, and persisted in 10% of the infants, whereas 37% were never infected. The corresponding figures for genital HPV infection were 36%, 14%, 1.5%, and 47%. Kaplan-Meier analysis revealed that both the cumulative incidence of infection and clearance of HPV were parallel in oral and genital sites. Persistent oral HPV infection in the child was significantly associated with persistent oral HPV infection in the mother at month 36 of follow-up, hand warts in the mother, young age at onset of sexual activity for the mother, and the mother's use of oral contraception, as well as with the father's oral HPV status at 24 months. Persistent genital HPV infection in the infant was predicted by if the mother had started smoking at 18–21 years of age and by a history of genital warts. Conclusions. Persistent carriage of high-risk HPV types was detected in oral and genital mucosa specimens obtained from 10% and 1.5% of the infants during their first 26 months of life. The rates of acquisition and clearance of HPV were similar in oral and genital mucosa.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/498114</identifier><identifier>PMID: 16288396</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Autoimmune diseases ; Babies ; Biological and medical sciences ; Carrier State ; Cervical cancer ; Child molestation ; Child, Preschool ; Children ; Children & youth ; Deoxyribonucleic acid ; DNA ; DNA Probes, HPV ; DNA, Viral - analysis ; Families & family life ; Female ; Finland ; Follow-Up Studies ; Genitalia ; Genitalia - chemistry ; Hospitals ; Human papillomavirus ; Humans ; Infant ; Infant, Newborn ; Infants ; Infections ; Infectious diseases ; Kaplan Meier estimator ; Major Articles ; Male ; Medical research ; Medical sciences ; Mouth Mucosa - chemistry ; Mucosa ; Mucous Membrane - chemistry ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomavirus infections ; Papillomavirus Infections - virology ; Parents ; Parents & parenting ; Polymerase chain reaction ; Prospective Studies ; Risk Factors ; Sexually transmitted diseases ; STD ; Warts</subject><ispartof>Clinical infectious diseases, 2005-12, Vol.41 (12), p.1728-1733</ispartof><rights>Copyright 2005 The Infectious Diseases Society of America</rights><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2006 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Dec 15, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-f55902981ede49a2a88b54dd7660bb4fe5f0be2d4502bede9c619fb57a165203</citedby><cites>FETCH-LOGICAL-c450t-f55902981ede49a2a88b54dd7660bb4fe5f0be2d4502bede9c619fb57a165203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4463660$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4463660$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17443036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16288396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rintala, Marjut A. M.</creatorcontrib><creatorcontrib>Grénman, Seija E.</creatorcontrib><creatorcontrib>Järvenkylä, Marja E.</creatorcontrib><creatorcontrib>Syrjänen, Kari J.</creatorcontrib><creatorcontrib>Syrjänen, Stina M.</creatorcontrib><title>High-Risk Types of Human Papillomavirus (HPV) DNA in Oral and Genital Mucosa of Infants during Their First 3 Years of Life: Experience from the Finnish HPV Family Study</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Background. This study is aimed to clarify data on the acquisition, persistence, and clearance of high-risk types of human papillomavirus (HPV) DNA from the mucosa and the determinants of persistent mucosal HPV infection in infants. Methods. Oral and genital scrapings from 324 infants were collected at birth, 3 days after delivery, and 1, 2, 6, 12, 24, and 36 months after delivery and tested for the presence of HPV DNA by nested polymerase chain reaction and hybridization with 12 high-risk HPV oligoprobes. HPV status and demographic data for parents were analyzed. Results. During the follow-up period (median duration, 26.2 months), HPV DNA was found to be present in 12%–21% of oral scrape samples and in 4%–15% of genital scrape samples obtained from the infants. Oral HPV infection was acquired by 42% of children, cleared by 11%, and persisted in 10% of the infants, whereas 37% were never infected. The corresponding figures for genital HPV infection were 36%, 14%, 1.5%, and 47%. Kaplan-Meier analysis revealed that both the cumulative incidence of infection and clearance of HPV were parallel in oral and genital sites. Persistent oral HPV infection in the child was significantly associated with persistent oral HPV infection in the mother at month 36 of follow-up, hand warts in the mother, young age at onset of sexual activity for the mother, and the mother's use of oral contraception, as well as with the father's oral HPV status at 24 months. Persistent genital HPV infection in the infant was predicted by if the mother had started smoking at 18–21 years of age and by a history of genital warts. Conclusions. Persistent carriage of high-risk HPV types was detected in oral and genital mucosa specimens obtained from 10% and 1.5% of the infants during their first 26 months of life. The rates of acquisition and clearance of HPV were similar in oral and genital mucosa.</description><subject>Autoimmune diseases</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Carrier State</subject><subject>Cervical cancer</subject><subject>Child molestation</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Probes, HPV</subject><subject>DNA, Viral - analysis</subject><subject>Families & family life</subject><subject>Female</subject><subject>Finland</subject><subject>Follow-Up Studies</subject><subject>Genitalia</subject><subject>Genitalia - chemistry</subject><subject>Hospitals</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Kaplan Meier estimator</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mouth Mucosa - chemistry</subject><subject>Mucosa</subject><subject>Mucous Membrane - chemistry</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus infections</subject><subject>Papillomavirus Infections - virology</subject><subject>Parents</subject><subject>Parents & parenting</subject><subject>Polymerase chain reaction</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Warts</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqF0c1u1DAQAOAIUdFS4AkQcpGo4BCw45843Kptt6m0tBVEFXCxnMTueps4wU5Q9414TLxk1ZWQECePNJ9nNDNR9ALB9why9oFkHCHyKDpAFKcxoxl6HGJIeUw45vvRU-9XECLEIX0S7SOWcI4zdhD9ys3tMv5s_B0o1r3yoNMgH1tpwbXsTdN0rfxp3OjB2_z65h04vTwBxoIrJxsgbQ3OlTVDiD-NVefl5vOF1dIOHtSjM_YWFEtlHJgb5weAwTcl3Z8WC6PVR3B23ytnlK0U0K5rwbBUgVpr_BKEdmAuW9OswZdhrNfPoj0tG6-eb9_DqJifFbM8XlydX8xOFnFFKBxiTWkGk7AMVSuSyURyXlJS1yljsCyJVlTDUiV1wEkZTFYxlOmSphIxmkB8GB1PZXvX_RiVH0RrfKWaRlrVjV4wziFLCPovRCniKMM0wNd_wVU3OhtmEAnKMpoSTnfVKtd575QWvTOtdGuBoNgcWEwHDvDVttpYtqrese1FA3izBdJXstFO2sr4nUsJwRBv3NHkurH_d7OXk1n5oXMPihCGwzpDOp7Sxg_q_iEt3Z1gKU6pyL9-F_CyyE_5DIsb_Bta1c14</recordid><startdate>20051215</startdate><enddate>20051215</enddate><creator>Rintala, Marjut A. 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M.</creatorcontrib><creatorcontrib>Grénman, Seija E.</creatorcontrib><creatorcontrib>Järvenkylä, Marja E.</creatorcontrib><creatorcontrib>Syrjänen, Kari J.</creatorcontrib><creatorcontrib>Syrjänen, Stina M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rintala, Marjut A. M.</au><au>Grénman, Seija E.</au><au>Järvenkylä, Marja E.</au><au>Syrjänen, Kari J.</au><au>Syrjänen, Stina M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-Risk Types of Human Papillomavirus (HPV) DNA in Oral and Genital Mucosa of Infants during Their First 3 Years of Life: Experience from the Finnish HPV Family Study</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2005-12-15</date><risdate>2005</risdate><volume>41</volume><issue>12</issue><spage>1728</spage><epage>1733</epage><pages>1728-1733</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Background. This study is aimed to clarify data on the acquisition, persistence, and clearance of high-risk types of human papillomavirus (HPV) DNA from the mucosa and the determinants of persistent mucosal HPV infection in infants. Methods. Oral and genital scrapings from 324 infants were collected at birth, 3 days after delivery, and 1, 2, 6, 12, 24, and 36 months after delivery and tested for the presence of HPV DNA by nested polymerase chain reaction and hybridization with 12 high-risk HPV oligoprobes. HPV status and demographic data for parents were analyzed. Results. During the follow-up period (median duration, 26.2 months), HPV DNA was found to be present in 12%–21% of oral scrape samples and in 4%–15% of genital scrape samples obtained from the infants. Oral HPV infection was acquired by 42% of children, cleared by 11%, and persisted in 10% of the infants, whereas 37% were never infected. The corresponding figures for genital HPV infection were 36%, 14%, 1.5%, and 47%. Kaplan-Meier analysis revealed that both the cumulative incidence of infection and clearance of HPV were parallel in oral and genital sites. Persistent oral HPV infection in the child was significantly associated with persistent oral HPV infection in the mother at month 36 of follow-up, hand warts in the mother, young age at onset of sexual activity for the mother, and the mother's use of oral contraception, as well as with the father's oral HPV status at 24 months. Persistent genital HPV infection in the infant was predicted by if the mother had started smoking at 18–21 years of age and by a history of genital warts. Conclusions. Persistent carriage of high-risk HPV types was detected in oral and genital mucosa specimens obtained from 10% and 1.5% of the infants during their first 26 months of life. The rates of acquisition and clearance of HPV were similar in oral and genital mucosa.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16288396</pmid><doi>10.1086/498114</doi><tpages>6</tpages></addata></record> |
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subjects | Autoimmune diseases Babies Biological and medical sciences Carrier State Cervical cancer Child molestation Child, Preschool Children Children & youth Deoxyribonucleic acid DNA DNA Probes, HPV DNA, Viral - analysis Families & family life Female Finland Follow-Up Studies Genitalia Genitalia - chemistry Hospitals Human papillomavirus Humans Infant Infant, Newborn Infants Infections Infectious diseases Kaplan Meier estimator Major Articles Male Medical research Medical sciences Mouth Mucosa - chemistry Mucosa Mucous Membrane - chemistry Papillomaviridae - classification Papillomaviridae - genetics Papillomavirus infections Papillomavirus Infections - virology Parents Parents & parenting Polymerase chain reaction Prospective Studies Risk Factors Sexually transmitted diseases STD Warts |
title | High-Risk Types of Human Papillomavirus (HPV) DNA in Oral and Genital Mucosa of Infants during Their First 3 Years of Life: Experience from the Finnish HPV Family Study |
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