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Effect of chymase on intraocular pressure in rabbits

Chymase is a chymotrypsin-like serine protease that is stored exclusively in the secretory granules of mast cells and converts big endothelins to endothelin-1 (1–31). The aim of this study was to evaluate the effect of chymase on intraocular pressure in rabbits. Chymase injection (3 and 10 mU) resul...

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Published in:European journal of pharmacology 2005-11, Vol.524 (1), p.132-137
Main Authors: Konno, Takashi, Maruichi, Midori, Takai, Shinji, Oku, Hidehiro, Sugiyama, Tetsuya, Uchibori, Takehiro, Nagai, Akihiko, Kogi, Kentaro, Ikeda, Tsunehiko, Miyazaki, Mizuo
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cited_by cdi_FETCH-LOGICAL-c390t-21a242dc1610bf601a90fdddcf875526b4c7dae3b98e2ff4a11e986754e58653
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container_title European journal of pharmacology
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creator Konno, Takashi
Maruichi, Midori
Takai, Shinji
Oku, Hidehiro
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Nagai, Akihiko
Kogi, Kentaro
Ikeda, Tsunehiko
Miyazaki, Mizuo
description Chymase is a chymotrypsin-like serine protease that is stored exclusively in the secretory granules of mast cells and converts big endothelins to endothelin-1 (1–31). The aim of this study was to evaluate the effect of chymase on intraocular pressure in rabbits. Chymase injection (3 and 10 mU) resulted in a trend toward increased intraocular pressure and a significant increase in intraocular pressure at a dose of 10 mU compared with the control. A specific chymase inhibitor, Suc-Val-Pro-Phe P(OPh) 2, attenuated the ocular hypertension induced by chymase. Endothelin-1 (1–31) also caused ocular hypertension, which was inhibited by a selective endothelin ET A receptor antagonist, cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123). Moreover, chymase-induced ocular hypertension was inhibited by BQ-123. These results suggest that chymase influences the regulation of intraocular pressure, and it is likely that the formation of endothelin-1 (1–31) and subsequent activation of endothelin ET A receptors are involved in the development of ocular hypertension induced by chymase.
doi_str_mv 10.1016/j.ejphar.2005.09.048
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subjects Animals
Antihypertensive Agents - pharmacology
Biological and medical sciences
Chymase
Chymases
Dose-Response Relationship, Drug
Endothelin ET A receptor
Endothelin Receptor Antagonists
Endothelin-1 (1–31)
Endothelin-1 - administration & dosage
Endothelin-1 - analogs & derivatives
Enzyme Inhibitors - pharmacology
Humans
Intraocular pressure
Intraocular Pressure - drug effects
Intraocular Pressure - physiology
Male
Medical sciences
Oligopeptides - pharmacology
Peptide Fragments - administration & dosage
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
Rabbits
Recombinant Proteins - administration & dosage
Serine Endopeptidases - administration & dosage
Serine Endopeptidases - genetics
Time Factors
title Effect of chymase on intraocular pressure in rabbits
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