Strain-specific mycobacterial lipids and the stimulation of protective immunity to tuberculosis

Control of Mycobacterium tuberculosis (M. tuberculosis) infection is dependent on recognition of bacilli by cells of the innate immune system in the lung and the subsequent generation of an acquired effector T lymphocyte response. Lipid moieties of M. tuberculosis are important stimulators of innate...

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Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2005-09, Vol.85 (5-6), p.407-413
Main Authors: Mendelson, Marc, Walters, Shaun, Smith, Issar, Kaplan, Gilla
Format: Article
Language:English
Subjects:
Antigen Presentation
Antigens, Bacterial - immunology
Humans
Immunity, Innate
Innate immunity
Lipid
Lipopolysaccharides - immunology
Lymphocyte Activation
Mycobacterium - immunology
Mycobacterium tuberculosis strain
Species Specificity
T-Lymphocytes - immunology
Toll-Like Receptors - metabolism
Tuberculosis - immunology
Virulence
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Summary:Control of Mycobacterium tuberculosis (M. tuberculosis) infection is dependent on recognition of bacilli by cells of the innate immune system in the lung and the subsequent generation of an acquired effector T lymphocyte response. Lipid moieties of M. tuberculosis are important stimulators of innate immunity mediated predominantly through recognition by Toll-like receptors. In this paper, we will discuss how the lipid composition of different clinical isolates (strains) of M. tuberculosis affect that strain's ability to direct innate immunity, and ultimately influence whether infection is controlled or active disease develops.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2005.08.004