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Synthesis, Characterization, and Biological Evaluation of M(I)(CO)3(NNO) Complexes (M = Re, 99mTc) Conjugated to 2-(4-Aminophenyl)benzothiazole as Potential Breast Cancer Radiopharmaceuticals
The synthesis and biological evaluation of new M(I)(CO)3(NNO) (M = Re, 99mTc) complexes attached to the antitumor agent 2-(4-aminophenyl)benzothiazole are reported. The fluorescent rhenium complex enters MCF-7 breast cancer cells but does not enter normal HFFF-2 and MRC-5 cells. The analogous radioa...
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| Published in: | Journal of medicinal chemistry 2006-09, Vol.49 (18), p.5408-5410 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a362t-167c4a94fc41bc95a35ea041f15160c37591ef810258b69e31e5fcf2d89222923 |
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| cites | cdi_FETCH-LOGICAL-a362t-167c4a94fc41bc95a35ea041f15160c37591ef810258b69e31e5fcf2d89222923 |
| container_end_page | 5410 |
| container_issue | 18 |
| container_start_page | 5408 |
| container_title | Journal of medicinal chemistry |
| container_volume | 49 |
| creator | Tzanopoulou, Stamatia Pirmettis, Ioannis C Patsis, George Paravatou-Petsotas, Maria Livaniou, Evangelia Papadopoulos, Minas Pelecanou, Maria |
| description | The synthesis and biological evaluation of new M(I)(CO)3(NNO) (M = Re, 99mTc) complexes attached to the antitumor agent 2-(4-aminophenyl)benzothiazole are reported. The fluorescent rhenium complex enters MCF-7 breast cancer cells but does not enter normal HFFF-2 and MRC-5 cells. The analogous radioactive 99mTc complex produces fast blood and soft tissue clearance when administered to healthy mice. These complexes are promising candidates for developing radiopharmaceuticals for imaging (99mTc) and targeted radiotherapy (186Re, 188Re) of breast cancer. |
| doi_str_mv | 10.1021/jm0606387 |
| format | article |
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The fluorescent rhenium complex enters MCF-7 breast cancer cells but does not enter normal HFFF-2 and MRC-5 cells. The analogous radioactive 99mTc complex produces fast blood and soft tissue clearance when administered to healthy mice. These complexes are promising candidates for developing radiopharmaceuticals for imaging (99mTc) and targeted radiotherapy (186Re, 188Re) of breast cancer.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm0606387</identifier><identifier>PMID: 16942013</identifier><identifier>CODEN: JMCMAR</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Benzothiazoles ; Biological and medical sciences ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - metabolism ; Cell Line ; Cell Line, Tumor ; Contrast media. 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Drug treatments ; Radiopharmaceuticals - chemical synthesis ; Radiopharmaceuticals - chemistry ; Radiopharmaceuticals - pharmacology ; Rhenium ; Structure-Activity Relationship ; Technetium ; Thiazoles - chemistry ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Journal of medicinal chemistry, 2006-09, Vol.49 (18), p.5408-5410</ispartof><rights>Copyright © 2006 American Chemical Society</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a362t-167c4a94fc41bc95a35ea041f15160c37591ef810258b69e31e5fcf2d89222923</citedby><cites>FETCH-LOGICAL-a362t-167c4a94fc41bc95a35ea041f15160c37591ef810258b69e31e5fcf2d89222923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18073824$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16942013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tzanopoulou, Stamatia</creatorcontrib><creatorcontrib>Pirmettis, Ioannis C</creatorcontrib><creatorcontrib>Patsis, George</creatorcontrib><creatorcontrib>Paravatou-Petsotas, Maria</creatorcontrib><creatorcontrib>Livaniou, Evangelia</creatorcontrib><creatorcontrib>Papadopoulos, Minas</creatorcontrib><creatorcontrib>Pelecanou, Maria</creatorcontrib><title>Synthesis, Characterization, and Biological Evaluation of M(I)(CO)3(NNO) Complexes (M = Re, 99mTc) Conjugated to 2-(4-Aminophenyl)benzothiazole as Potential Breast Cancer Radiopharmaceuticals</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>The synthesis and biological evaluation of new M(I)(CO)3(NNO) (M = Re, 99mTc) complexes attached to the antitumor agent 2-(4-aminophenyl)benzothiazole are reported. The fluorescent rhenium complex enters MCF-7 breast cancer cells but does not enter normal HFFF-2 and MRC-5 cells. The analogous radioactive 99mTc complex produces fast blood and soft tissue clearance when administered to healthy mice. These complexes are promising candidates for developing radiopharmaceuticals for imaging (99mTc) and targeted radiotherapy (186Re, 188Re) of breast cancer.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Benzothiazoles</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Female</subject><subject>Fibroblasts - metabolism</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Organometallic Compounds - chemical synthesis</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiopharmaceuticals - chemical synthesis</subject><subject>Radiopharmaceuticals - chemistry</subject><subject>Radiopharmaceuticals - pharmacology</subject><subject>Rhenium</subject><subject>Structure-Activity Relationship</subject><subject>Technetium</subject><subject>Thiazoles - chemistry</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNptkc1u00AUhS0EoqGw4AXQbECxFMP82I69YNFaBar-pLRBYje6mVw3k9qeMDNGTV6OV2NCombD6i7ON2fuPSeK3jL6kVHOPi1bmtNcFONn0YBlnCZpQdPn0YBSzhOec3EUvXJuSSkVjIuX0RHLy5RTJgbRn7t15xfotBuRagEWlEerN-C16UYEujk51aYx91pBQ85-Q9P_k4ipydXwPB5Wk1gMr68nMalMu2rwER0ZXpHP5BZHpCzbqdoq3bK_B49z4g3hyTBNTlrdmdUCu3UTz7DbGL_QsDENEnDkxnjsvA4fnloE50kFnUJLbmGuwyOwLSjs_XYl9zp6UYeBb_bzOPrx5WxafUsuJ1_Pq5PLBETOfcLysUqhTGuVspkqMxAZAk1ZzTKWUyXGWcmwLkKaWTHLSxQMs1rVfF6UnPOSi-Pow853Zc2vHp2XrXYKmwY6NL2TeVEwkbEsgPEOVNY4Z7GWK6tbsGvJqNy2JZ_aCuy7vWk_a3F-IPf1BOD9HgAXrq1tCEK7A1fQsSh4Grhkx2nn8fFJB_sg83E4Tk5v7uRFlX4Xxc8LmR18QTm5NL3tQnb_WfAvjFq17A</recordid><startdate>20060907</startdate><enddate>20060907</enddate><creator>Tzanopoulou, Stamatia</creator><creator>Pirmettis, Ioannis C</creator><creator>Patsis, George</creator><creator>Paravatou-Petsotas, Maria</creator><creator>Livaniou, Evangelia</creator><creator>Papadopoulos, Minas</creator><creator>Pelecanou, Maria</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060907</creationdate><title>Synthesis, Characterization, and Biological Evaluation of M(I)(CO)3(NNO) Complexes (M = Re, 99mTc) Conjugated to 2-(4-Aminophenyl)benzothiazole as Potential Breast Cancer Radiopharmaceuticals</title><author>Tzanopoulou, Stamatia ; Pirmettis, Ioannis C ; Patsis, George ; Paravatou-Petsotas, Maria ; Livaniou, Evangelia ; Papadopoulos, Minas ; Pelecanou, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a362t-167c4a94fc41bc95a35ea041f15160c37591ef810258b69e31e5fcf2d89222923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Benzothiazoles</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cell Line</topic><topic>Cell Line, Tumor</topic><topic>Contrast media. 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Med. Chem</addtitle><date>2006-09-07</date><risdate>2006</risdate><volume>49</volume><issue>18</issue><spage>5408</spage><epage>5410</epage><pages>5408-5410</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><coden>JMCMAR</coden><abstract>The synthesis and biological evaluation of new M(I)(CO)3(NNO) (M = Re, 99mTc) complexes attached to the antitumor agent 2-(4-aminophenyl)benzothiazole are reported. The fluorescent rhenium complex enters MCF-7 breast cancer cells but does not enter normal HFFF-2 and MRC-5 cells. The analogous radioactive 99mTc complex produces fast blood and soft tissue clearance when administered to healthy mice. These complexes are promising candidates for developing radiopharmaceuticals for imaging (99mTc) and targeted radiotherapy (186Re, 188Re) of breast cancer.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>16942013</pmid><doi>10.1021/jm0606387</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of medicinal chemistry, 2006-09, Vol.49 (18), p.5408-5410 |
| issn | 0022-2623 1520-4804 |
| language | eng |
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| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzothiazoles Biological and medical sciences Breast Neoplasms - diagnostic imaging Breast Neoplasms - metabolism Cell Line Cell Line, Tumor Contrast media. Radiopharmaceuticals Female Fibroblasts - metabolism Humans Medical sciences Mice Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Pharmacology. Drug treatments Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacology Rhenium Structure-Activity Relationship Technetium Thiazoles - chemistry Tomography, Emission-Computed, Single-Photon |
| title | Synthesis, Characterization, and Biological Evaluation of M(I)(CO)3(NNO) Complexes (M = Re, 99mTc) Conjugated to 2-(4-Aminophenyl)benzothiazole as Potential Breast Cancer Radiopharmaceuticals |
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