Rate Enhancement by Ethylene in the Ru-Catalyzed Ring-Closing Metathesis of Enynes: Evidence for an "Ene-then-Yne" Pathway that Diverts through a Second Catalytic Cycle

Mixing it: A dual‐substrate/dual isotopic labeling strategy has shown that the accelerating effect of ethylene in intermolecular ring‐closing metathesis of enynes is best explained by an ene‐then‐yne mechanism rather than the commonly proposed yne‐then‐ene mechanism (see picture).

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-12, Vol.44 (45), p.7442-7447
Main Authors: Lloyd-Jones, Guy C., Margue, Robert G., de Vries, Johannes G.
Format: Article
Language:English
Subjects:
carbenes
isotopic labeling
metathesis
reaction mechanisms
ruthenium
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Summary:Mixing it: A dual‐substrate/dual isotopic labeling strategy has shown that the accelerating effect of ethylene in intermolecular ring‐closing metathesis of enynes is best explained by an ene‐then‐yne mechanism rather than the commonly proposed yne‐then‐ene mechanism (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502243