Comparison among tomographic radionuclide ventriculography algorithms for computing left and right ventricular normal limits

Various algorithms have been developed to compute right ventricular (RV) and left ventricular (LV) end-diastolic volumes, end-systolic volumes, and ejection fractions (EF) from tomographic radionuclide ventriculography (TRV). The aims of this investigation were to establish sex-specific normal limit...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2006-09, Vol.13 (5), p.675-684
Main Authors: De Bondt, Pieter, Nichols, Kenneth J., De Winter, Olivier, De Sutter, Johan, Vanderheyden, Marc, Akinboboye, Olakunle O., Dierckx, Rudi Andre
Format: Article
Language:English
Subjects:
Adult
Aged
Algorithms
Automation
cardiac volumes
ejection fraction
Female
gated blood-pool SPECT
Humans
left ventricle
Male
Middle Aged
Normal limits
Prospective Studies
Reference Values
right ventricle
Sex Factors
Tomography, X-Ray Computed - methods
Ventricular Function, Left
Ventricular Function, Right
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Summary:Various algorithms have been developed to compute right ventricular (RV) and left ventricular (LV) end-diastolic volumes, end-systolic volumes, and ejection fractions (EF) from tomographic radionuclide ventriculography (TRV). The aims of this investigation were to establish sex-specific normal limits, to determine whether different algorithms produce the same normal values, and to compare TRV normal limits vs for magnetic resonance imaging values in the literature. Fifty-one healthy volunteers (29 men, 22 women) were studied prospectively. All subjects had normal electrocardiograms and echocardiographic examinations, and underwent both planar radionuclide ventriculography and TRV. Four algorithms were used to process TRV data. Normal limits for most functional parameters differed significantly from one algorithm to another. Volumes were greater in men, but no statistically significant differences were found between men and women for LV EF or RV EF values for any method. Normal LV and RV EF and volumes were largely consistent with the literature for cardiac magnetic resonance imaging. Ventricular measurements differ significantly among TRV algorithms. Therefore, it is important to apply sex-specific normal limits that are specific to a given TRV algorithm in interpreting LV and RV EF and volume measurements for each patient.
ISSN:1071-3581
1532-6551
DOI:10.1016/j.nuclcard.2006.06.135