Small-Molecule Diversification from Iterated Branching Reaction Pathways Enabled by DNA-Templated Synthesis

Two unique features of DNA‐templated synthesis were integrated to prepare complex small molecules by using iterated branching reaction pathways: the direction of multiple, otherwise “incompatible”, reaction types in one reaction vessel and the direction of sequence‐programmed subsets of reaction int...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-12, Vol.44 (45), p.7383-7386
Main Authors: Calderone, Christopher T., Liu, David R.
Format: Article
Language:English
Subjects:
Amines - chemical synthesis
Amines - chemistry
bioorganic chemistry
combinatorial chemistry
diversity-oriented synthesis
DNA
DNA Primers - chemistry
Molecular Structure
Molecular Weight
template synthesis
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Summary:Two unique features of DNA‐templated synthesis were integrated to prepare complex small molecules by using iterated branching reaction pathways: the direction of multiple, otherwise “incompatible”, reaction types in one reaction vessel and the direction of sequence‐programmed subsets of reaction intermediates to appropriate reagents.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502899