Loading…
Endothelial function is impaired in patients with primary antiphospholipid syndrome
The aim of this study was to evaluate endothelial function in patients with primary antiphospholipid syndrome (PAPS). Flow mediated (FMD) and glyceryl trinitrate (GTN) induced dilation of the right brachial artery were studied in 25 patients with PAPS and 25 controls matched by age, sex and conventi...
Saved in:
Published in: | Thrombosis research 2006, Vol.118 (4), p.455-461 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The aim of this study was to evaluate endothelial function in patients with primary antiphospholipid syndrome (PAPS).
Flow mediated (FMD) and glyceryl trinitrate (GTN) induced dilation of the right brachial artery were studied in 25 patients with PAPS and 25 controls matched by age, sex and conventional risk factors for atherosclerosis. Fibrinogen, D-dimer, adhesion molecules, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigens and activities were measured.
Mean (SD) FMD was significantly lower in PAPS than in controls (8
±
5% vs. 15
±
6%,
P
<
0.001); GTN-induced dilation did not differ between the groups. There was a correlation between the baseline diameter of the brachial artery and duration of the disease (−
0.56,
P
<
0.05) and between GTN induced dilation and duration of the disease (0.51,
P
<
0.05). Concentrations of vascular cell adhesion molecule-1 (
P
<
0.001), intracellular adhesion molecule-1 (
P
<
0.001) and fibrinogen (
P
<
0.05) were higher in patients than in controls but no differences were observed for D-dimer, t-PA and PAI-1 antigens and activities. There was correlation between concentration of vascular cell adhesion molecule-1 and FMD (−
0.35,
P
<
0.05) and between intracellular adhesion molecule-1 and FMD (−
0.41,
P
<
0.05).
This study shows that endothelial function is impaired in patients with primary APS, possibly contributing to accelerated atherosclerosis and thromboembolic complications in these patients. |
---|---|
ISSN: | 0049-3848 1879-2472 |
DOI: | 10.1016/j.thromres.2005.09.005 |