role of first line of defence mechanisms in the pathogenesis of cellulitis in broiler chickens: skin structural, physiological and cellular response factors

• Published in: Journal of veterinary medicine. Series A 2005-12, Vol.52 (10), p.517-524
• Main Authors: Olkowski, A.A, Wojnarowicz, C, Chirino-Trejo, M, Wurtz, B.M, Kumor, L
• Format: Article
• Language: English
• Subjects: Animals; bacterial colonization; broiler chickens; cellulitis; Cellulitis - genetics; Cellulitis - immunology; Cellulitis - veterinary; Chickens - genetics; disease resistance; Escherichia coli; Escherichia infections; Genetic Predisposition to Disease; heterophils; histopathology; immune response; Immunity, Innate - genetics; Male; pathogenesis; Pedigree; phagocytes; phagocytosis; physiological response; poultry diseases; Poultry Diseases - genetics; Poultry Diseases - immunology; resistance mechanisms; risk factors; skin; Skin - cytology; Skin - pathology; Skin - ultrastructure; skin lesions; Skin Physiological Phenomena; ultrastructure; Wound Healing - physiology
• ISSN: 0931-184X; 1439-0442
• DOI: 10.1111/j.1439-0442.2005.00768.x

The present study examined several basic attributes of first-line defence mechanisms in the skin as potential factors that may explain the susceptibility of broiler chickens to cellulitis. The variables including structural characteristics of the skin, physicochemical properties and cellular responses to the challenge with pathogens were compared between two categories of chickens, a strain of fast-growing commercial broiler chickens (susceptible to cellulitis) and leghorn chickens (resistant to cellulitis). There were substantial differences between leghorns and broilers with regard to physiological characteristics of the skin. Broiler skin was more amenable to injury and the wound-healing process was slow. Compared with leghorns, the lesions resulting from sub-dermal challenge in broilers were more severe and disseminated over a larger area. Mobilization of phagocytic cells (heterophils and macrophages) in leghorns was brisk even in the areas distant from the site of infection, whereas only few heterophils were recruited in the skin of broilers. The functional competence of heterophils in broilers was inferior when compared with leghorns. Based on the present finding, the predisposition of broilers to cellulitis appears to be primarily associated with the inferior first line of defence of their skin. Broilers in commercial situations may be at higher risk to succumb to even minor infection and eventually develop cellulitis because: (1) structural weaknesses of the skin may predispose broilers to skin injury and thus the risk of skin infection by pathogens is increased; (2) broiler skin surface is more likely to provide a conducive environment for colonization of Escherichia coli; (3) in the event of infection, poor recruitment of phagocytic cells to the site of infection may readily lead to widespread colonization of the tissue by pathogens causing cellulitis and (4) poor functional quality of the phagocytic cells that are mobilized compromise the ability of the host to contain the spread of infection.