Analysis of epistasis for diabetic nephropathy among type 2 diabetic patients

Diabetic nephropathy (DN) is one of the most serious complications of diabetes, accounting for the majority of patients with end-stage renal disease. The molecular pathogenesis of DN involves multiple pathways in a complex, partially resolved manner. The paper presents an exploratory epistatic study...

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Bibliographic Details
Published in:Human molecular genetics 2006-09, Vol.15 (18), p.2701-2708
Main Authors: Hsieh, Chang-Hsun, Liang, Kung-Hao, Hung, Yi-Jen, Huang, Li-Chin, Pei, Dee, Liao, Ya-Tang, Kuo, Shi-Wen, Bey, Monica Shian-Jy, Chen, Jui-Lin, Chen, Ellson Y.
Format: Article
Language:English
Subjects:
Aged
Algorithms
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Case-Control Studies
Cohort Studies
Diabetes Mellitus, Type 2 - genetics
Diabetic Nephropathies - etiology
Diabetic Nephropathies - genetics
Epistasis, Genetic
Female
Fundamental and applied biological sciences. Psychology
Genes, erbB-1
Genetics of eukaryotes. Biological and molecular evolution
Haplotypes
Humans
Kidneys
Linkage Disequilibrium
Male
Medical sciences
Middle Aged
Molecular and cellular biology
Nephrology. Urinary tract diseases
Polymorphism, Single Nucleotide
Retinoid X Receptor gamma - genetics
Taiwan
Urinary system involvement in other diseases. Miscellaneous
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Summary:Diabetic nephropathy (DN) is one of the most serious complications of diabetes, accounting for the majority of patients with end-stage renal disease. The molecular pathogenesis of DN involves multiple pathways in a complex, partially resolved manner. The paper presents an exploratory epistatic study for DN. Association analysis were performed on 231 SNP loci in a cohort of 264 type 2 diabetes patients, followed by the epistasis analysis using the multifactor dimensionality reduction and the genetic algorithm with Boolean algebra. A two-locus epistatic effect of EGFR and RXRG was identified, with a cross-validation consistency of 91.7%.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddl203