Atypical glandular cells: criteria to discriminate benign from neoplastic lesions and squamous from glandular neoplasia

Objective:  To evaluate the presence of some criteria in cervical smears with atypical glandular cells and their correlation with histological patterns to identify pre‐neoplastic and neoplastic lesions. Methods:  Seventy‐three women referred with an atypical glandular cell smear, who had undergone c...

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Bibliographic Details
Published in:Cytopathology (Oxford) 2005-12, Vol.16 (6), p.295-302
Main Authors: Torres, J. C. C., Derchain, S. F. M., Gontijo, R. C., Do Amaral Westin, M. C., Zeferino, L. C., Angelo-Andrade, L. A. L., Rabelo-Santos, S. H.
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
atypical glandular cells
Carcinoma, Squamous Cell - pathology
Cervical Intraepithelial Neoplasia - pathology
cervical smear
Cervix Uteri - pathology
Cross-Sectional Studies
cyto-morphological criteria
Cytodiagnosis - methods
Diagnosis, Differential
Female
Humans
intraepithelial or invasive neoplasia
Logistic Models
Middle Aged
Papanicolaou Test
Uterine Cervical Neoplasms - pathology
Vaginal Smears
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Summary:Objective:  To evaluate the presence of some criteria in cervical smears with atypical glandular cells and their correlation with histological patterns to identify pre‐neoplastic and neoplastic lesions. Methods:  Seventy‐three women referred with an atypical glandular cell smear, who had undergone conization or hysterectomy, were included in this study. Referral Pap smears were reviewed using the set of 27 cyto‐morphological criteria that was correlated with the histological diagnosis. Results:  Histological results showed intraepithelial or invasive neoplasia in 35 (48%) cases and benign lesions in 38 (52%) cases. After logistic regression and decision tree analysis an increased nuclear/cytoplasmic ratio and the presence of dyskeratotic cells were strongly associated with intraepithelial or invasive neoplasia and the differential cyto‐morphological criteria for glandular lesions were decreased cytoplasm, irregular nuclear membranes and the presence of nucleoli. Conclusion:  The analysis of individual cyto‐morphological criteria can better predict intraepithelial or invasive neoplasia and differentiate glandular from squamous lesions.
ISSN:0956-5507
1365-2303
DOI:10.1111/j.1365-2303.2005.00300.x