Inductin of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat

Neuron-derived orphan receptor (NOR-1) is a member of the thyroid/steroid receptor superfamily that was originally identified in forebrain neuronal cells undergoing apoptosis. In addition to apoptotic stimuli, activation of several signal transduction pathways including direct neuronal depolarizatio...

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Published in:Molecules and cells 2006-08, Vol.22 (1), p.8-12
Main Authors: Kim, Y.H. (Korea University, Seoul, Republic of Korea), Hong, S.T. (Korea University, Seoul, Republic of Korea), Noh, M.R. (Korea University, Seoul, Republic of Korea), Kim, S.Y. (Korea University, Seoul, Republic of Korea), Huh, P.W. (Uijongbu St. Mary's Hospital, Catholic University, Uijongbu, Republic of Korea), Park, S.H. (Korea University, Seoul, Republic of Korea), Sun, W. (Korea University, Seoul, Republic of Korea), Kim, H. (Korea University, Seoul, Republic of Korea), E-mail: kimhyun@korea.ac.kr
Format: Article
Language:English
Subjects:
Animals
ANOXIA
ANOXIE
Cells, Cultured
Dentate Gyrus - metabolism
Depolarization
DNA-Binding Proteins - biosynthesis
Ischemic Attack, Transient - physiopathology
Male
Nerve Tissue Proteins - biosynthesis
NOR-1
OGD
Proto-Oncogene Proteins c-fos - biosynthesis
Rats
Rats, Sprague-Dawley
Signal Transduction
Transient Global Ischemia
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Summary:Neuron-derived orphan receptor (NOR-1) is a member of the thyroid/steroid receptor superfamily that was originally identified in forebrain neuronal cells undergoing apoptosis. In addition to apoptotic stimuli, activation of several signal transduction pathways including direct neuronal depolarization regulates the expression of NOR-1. In this study we tested whether the expression of NOR-1 is changed following transient ischemic injury in the adult rat brain. NOR-1 mRNA increased rapidly in the dentate gyrus of the hippocampal formation and piriform cortex 3 h after transient global ischemia and returned to basal level at 6 h.
ISSN:1016-8478