Inductin of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat

• Published in: Molecules and cells 2006-08, Vol.22 (1), p.8-12
• Main Authors: Kim, Y.H. (Korea University, Seoul, Republic of Korea), Hong, S.T. (Korea University, Seoul, Republic of Korea), Noh, M.R. (Korea University, Seoul, Republic of Korea), Kim, S.Y. (Korea University, Seoul, Republic of Korea), Huh, P.W. (Uijongbu St. Mary's Hospital, Catholic University, Uijongbu, Republic of Korea), Park, S.H. (Korea University, Seoul, Republic of Korea), Sun, W. (Korea University, Seoul, Republic of Korea), Kim, H. (Korea University, Seoul, Republic of Korea), E-mail: [e-mail]
• Format: Article
• Language: English
• Subjects: Animals; ANOXIA; ANOXIE; Cells, Cultured; Dentate Gyrus - metabolism; Depolarization; DNA-Binding Proteins - biosynthesis; Ischemic Attack, Transient - physiopathology; Male; Nerve Tissue Proteins - biosynthesis; NOR-1; OGD; Proto-Oncogene Proteins c-fos - biosynthesis; Rats; Rats, Sprague-Dawley; Signal Transduction; Transient Global Ischemia
• ISSN: 1016-8478

Neuron-derived orphan receptor (NOR-1) is a member of the thyroid/steroid receptor superfamily that was originally identified in forebrain neuronal cells undergoing apoptosis. In addition to apoptotic stimuli, activation of several signal transduction pathways including direct neuronal depolarization regulates the expression of NOR-1. In this study we tested whether the expression of NOR-1 is changed following transient ischemic injury in the adult rat brain. NOR-1 mRNA increased rapidly in the dentate gyrus of the hippocampal formation and piriform cortex 3 h after transient global ischemia and returned to basal level at 6 h.