Middle-Aged Children of Persons With Alzheimer’s Disease: APOE Genotypes and Cognitive Function in the Wisconsin Registry for Alzheimer’s Prevention

• Published in: Journal of geriatric psychiatry and neurology 2005-12, Vol.18 (4), p.245-249
• Main Authors: Sager, Mark A., Hermann, Bruce, La Rue, Asenath
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - etiology; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E4; Apolipoproteins; Apolipoproteins E - genetics; Cognition; Cognition Disorders - genetics; Cohort Studies; Female; Genetic Predisposition to Disease; Genotype; Health aspects; Humans; Male; Middle Aged; Registries - statistics & numerical data
• ISSN: 0891-9887; 1552-5708
• DOI: 10.1177/0891988705281882

Adult children of persons with Alzheimer’s disease are at increased risk of developing Alzheimer’s disease because of hereditary, environmental, and health risk factors shared with affected parents. The Wisconsin Registry for Alzheimer’s Prevention (WRAP) has completed baseline assessments on 452 middle-aged persons (mean = 53 years) who have at least 1 parent with AD. Forty-five percent had 1 or more apolipoprotein (APOE) ε4 alleles. There were few significant differences between ε4 carriers and noncarriers in demographics, health, and lifestyle measures or in neuropsychological performance. The high percentage of WRAP participants who are carriers of APOE ε4 underscores their increased risk for developing Alzheimer’s disease, but the absence of differences related to APOE status and high mean scores on cognitive tests suggests that the APOE ε4 gene has yet to have a clinical impact on cognitive functioning. The WRAP cohort may be a valuable group to follow prospectively to characterize the nature of cognitive change in relation to risk factors and to identify underlying preclinical neurobiological changes.