Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes

Aims/hypothesis We determined whether oxidative damage in collagen is increased in (1) patients with diabetes; (2) patients with diabetic complications; and (3) subjects from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study, wi...

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Published in:Diabetologia 2006-10, Vol.49 (10), p.2488-2498
Main Authors: Yu, Y, Thorpe, S. R, Jenkins, A. J, Shaw, J. N, Sochaski, M. A, McGee, D, Aston, C. E, Orchard, T. J, Silvers, N, Peng, Y. G, McKnight, J. A, Baynes, J. W, Lyons, T. J
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biopsy
Cholesterol, HDL - blood
Cholesterol, LDL - blood
collagen
Collagen - chemistry
Collagen - metabolism
Diabetes complications
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 1 - pathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glycated Hemoglobin A - analysis
glycation
Glycation End Products, Advanced - metabolism
Humans
Male
Medical sciences
Methionine - analogs & derivatives
Methionine - metabolism
Methionine sulphoxide
Middle Aged
oxidative stress
Reference Values
Skin - metabolism
Skin - pathology
Triglycerides - blood
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Summary:Aims/hypothesis We determined whether oxidative damage in collagen is increased in (1) patients with diabetes; (2) patients with diabetic complications; and (3) subjects from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study, with comparison of subjects from the former standard vs intensive treatment groups 4 years after DCCT completion. Subjects, materials and methods We quantified the early glycation product fructose-lysine, the two AGEs N ε-(carboxymethyl)lysine (CML) and pentosidine, and the oxidised amino acid methionine sulphoxide (MetSO) in skin collagen from 96 patients with type 1 diabetes (taken from three groups: DCCT/EDIC patients and clinic patients from South Carolina and Scotland) and from 78 healthy subjects. Results Fructose-lysine was increased in diabetic patients (p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-006-0355-8