Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

In order to characterize immunoglobulin heavy‐chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non‐human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study repo...

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Bibliographic Details
Published in:Tissue antigens 2005-12, Vol.66 (6), p.640-649
Main Authors: Hernández, E. C., Suárez, C. F., Parra, C. A., Patarroyo, M. A., Patarroyo, M. E.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
animal model
Animals
Antibody Diversity - genetics
Aotidae - genetics
Aotidae - immunology
Aotus
Aotus nancymaae
Cloning, Molecular
Genes, Immunoglobulin
Humans
IGHV
Immunoglobulin Heavy Chains - genetics
Immunoglobulin Variable Region - genetics
molecular evolution
Molecular Sequence Data
Multigene Family
New World monkey
Phylogeny
Polymerase Chain Reaction
Primates
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sequence Homology, Amino Acid
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Summary:In order to characterize immunoglobulin heavy‐chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non‐human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.2005.00491.x