Anaphase Promoting Complex or Cyclosome?

The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new f...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2005-11, Vol.4 (11), p.1585-1592
Main Authors: Clarke, Duncan J., Díaz-Martínez, Laura A., Gimenez-Abian, Juan F.
Format: Article
Language:English
Subjects:
Anaphase - genetics
Anaphase - physiology
Anaphase-Promoting Complex-Cyclosome
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cells, Cultured
Cycle
Evolution, Molecular
Humans
Landes
Organogenesis
Proteins
Ubiquitin-Protein Ligase Complexes - chemistry
Ubiquitin-Protein Ligase Complexes - genetics
Ubiquitin-Protein Ligase Complexes - metabolism
Ubiquitin-Protein Ligase Complexes - physiology
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Summary:The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C. Moreover, sister centromere separation can occur in the absence of APC/C activity in mammals, indicating that anaphase onset might be triggered by multiple factors. Here we discuss whether the APC/C functions primarily as the anaphase trigger, or whether it has more general properties, relevant for cell cycle control at multiple developmental and cell cycle stages. Additionally, we discuss the validity of the APC-dependent model for sister segregation in mammals.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.4.11.2143