Effect of cardiac resynchronization therapy on sleep quality, quality of life, and symptomatic depression in patients with chronic heart failure and Cheyne-Stokes respiration

Patients with heart failure (HF) often suffer from sleep-related breathing disorders (SRBD) like Cheyne-Stokes respiration (CSR). Cardiac resynchronization therapy (CRT) improves myocardial function and exercise capacity in patients with HF and conduction disturbances. As CRT has been shown to reduc...

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Bibliographic Details
Published in:Sleep & breathing 2005-12, Vol.9 (4), p.159-166
Main Authors: SKOBEL, Erik C, SINHA, Anil-Martin, NORRA, Christine, RANDERATH, Winfried, BREITHARDT, Ole-Alexander, BREUER, Christian, HANRATH, Peter, STELLBRINK, Christoph
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiac Pacing, Artificial
Cheyne-Stokes Respiration - epidemiology
Cheyne-Stokes Respiration - physiopathology
Chronic Disease
Depression - diagnosis
Depression - epidemiology
Depression - psychology
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
Heart failure
Heart Failure - epidemiology
Heart Failure - physiopathology
Heart Failure - therapy
Heart Rate - physiology
Humans
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Polysomnography
Posture
Quality of life
Quality of Life - psychology
Sleep - physiology
Sleep Apnea Syndromes - epidemiology
Sleep Apnea Syndromes - physiopathology
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Summary:Patients with heart failure (HF) often suffer from sleep-related breathing disorders (SRBD) like Cheyne-Stokes respiration (CSR). Cardiac resynchronization therapy (CRT) improves myocardial function and exercise capacity in patients with HF and conduction disturbances. As CRT has been shown to reduce CSR in patients with HF, it is not clear whether CRT improves quality of life and symptomatic depression by improvement of apnea/hypopnea index (AHI) and sleep quality. Forty-two HF patients with conduction disturbance before CRT were screened for CSR and evaluated for sleep quality [Pittsburgh Sleep Quality Index (PSQI)], quality of life score [36-item short form (SF-36)], depression, and exercise capacity (VO2 peak) and ejection fraction (EF). Eighteen patients (three females, age 61+/-10, body mass index 24+/-4 kg m(-2), EF 24+/-4%, QRS complex duration 156+/-32 ms) presented CSR with an AHI of 18+/-8 (11 CSR, 7 mixed). Fourteen patients showed no SRBD (PSQI
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-005-0030-1