Increase in slow afterhyperpolarization led to learning delay in DBA mice

We showed that differences in learning capacity between DBA and C57Bl/6 mice correlates with differences in slow afterhyperpolarization amplitude in hippocampal CA1 pyramid neurons. In DBA mice learning capacity is lower, but the amplitude of slow afterhyperpolarizations higher than in C57Bl/6 mice.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2005-09, Vol.140 (3), p.274-277
Main Authors: Oksman, G Y, Li, K, Rose, G, Skrebitsky, V G, Fedorov, N B
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Escape Reaction
Hippocampus - physiology
Learning - physiology
Long-Term Potentiation - physiology
Membrane Potentials
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Synaptic Transmission
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Summary:We showed that differences in learning capacity between DBA and C57Bl/6 mice correlates with differences in slow afterhyperpolarization amplitude in hippocampal CA1 pyramid neurons. In DBA mice learning capacity is lower, but the amplitude of slow afterhyperpolarizations higher than in C57Bl/6 mice.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0465-1