Association of Excess Weight and Degree of Airway Responsiveness in Asthmatics and Non-Asthmatics

It is unclear whether obesity is associated with increasing degree of airway responsiveness in asthmatics. In this study, methacholine challenge test results of 1,725 subjects with respiratory symptoms were reviewed. Obesity was associated with asthma with an odds ratio of 1.72 (95% C.I. 1.36, 2.17)...

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Bibliographic Details
Published in:The Journal of asthma 2006-01, Vol.43 (6), p.447-452
Main Authors: Sood, Akshay, Verhulst, Steven J., Varma, Adarsh, Eagleton, Lanie E., Henkle, Joseph Q., Hopkins-Price, Patricia
Format: Article
Language:English
Subjects:
Adult
Aged
airway hyperreactivity
airway responsiveness
asthma
Asthma - physiopathology
Body Mass Index
Bronchial Hyperreactivity - etiology
Female
Forced Expiratory Volume
Humans
Male
methacholine challenge
Methacholine Chloride - pharmacology
Middle Aged
obesity
Obesity - complications
Retrospective Studies
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Summary:It is unclear whether obesity is associated with increasing degree of airway responsiveness in asthmatics. In this study, methacholine challenge test results of 1,725 subjects with respiratory symptoms were reviewed. Obesity was associated with asthma with an odds ratio of 1.72 (95% C.I. 1.36, 2.17). Although there was a significant difference in the degree of airway responsiveness between various body mass index categories of non-asthmatics (p = 0.01), no significant difference was noted among asthmatics (p = 0.93). A weakly significant interaction between asthma status and body mass index on the degree of airway responsiveness was noted (p = 0.08).
ISSN:0277-0903
1532-4303
DOI:10.1080/02770900600758309