Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma) : a case report and review of the literature

We describe a rare hepatic collision tumor composed of a hepatocellular carcinoma and a high-grade neuroendocrine carcinoma. The patient, a 50-year-old man, underwent a partial hepatectomy because of a 5.0-cm mass. The tumor had two distinctive patterns. The majority of the tumor was a high-grade ne...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2006-09, Vol.449 (3), p.376-381
Main Authors: GARCIA, Monica T, BEJARANO, Pablo A, YSSA, Maria, BUITRAGO, Efren, LIVINGSTONE, Alan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Cancer
Carcinoma, Hepatocellular - chemistry
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Carcinoma, Neuroendocrine - chemistry
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - surgery
Chromogranins - analysis
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
Investigative techniques, diagnostic techniques (general aspects)
Keratin-19 - analysis
Liver Neoplasms - chemistry
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Neoplasms, Multiple Primary
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Synaptophysin - analysis
Tumors
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Summary:We describe a rare hepatic collision tumor composed of a hepatocellular carcinoma and a high-grade neuroendocrine carcinoma. The patient, a 50-year-old man, underwent a partial hepatectomy because of a 5.0-cm mass. The tumor had two distinctive patterns. The majority of the tumor was a high-grade neuroendocrine carcinoma with features of a small cell carcinoma that was positive for chromogranin, synaptophysin, and cytokeratin 19 and negative for hepatocellular antigen and alpha-fetoprotein (AFP). The second component was a moderately differentiated hepatocellular carcinoma that was positive for hepatocellular antigen and AFP and negative for neuroendocrine markers. The two tumors were separated by fibrous bands. In areas where they collided, there was no transition or intermingling of cells between the two components, thus, it is different from the combined type of tumors. After removal of the tumor, the patient had intrahepatic and mesenteric recurrences within a follow-up period of 16 months.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-006-0251-0