Distant Metastasis from Subcutaneously Grown E0771 Medullary Breast Adenocarcinoma

Background: Breast cancer treatments are most effective when initiated early, with very poor efficacy against metastatic disease. In seeking a readily metastasizing mouse breast cancer model to facilitate the search for effective therapies, E0771 medullary adenocarcinomas implanted subcutaneously in...

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Bibliographic Details
Published in:Anticancer research 2005-11, Vol.25 (6B), p.3905-3915
Main Authors: EWENS, Andrew, MIHICH, Enrico, EHRKE, M. Jane
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinoma, Medullary - immunology
Carcinoma, Medullary - pathology
Carcinoma, Medullary - secondary
Cell Growth Processes - physiology
Female
Gynecology. Andrology. Obstetrics
Lung Neoplasms - immunology
Lung Neoplasms - pathology
Lung Neoplasms - secondary
Mammary gland diseases
Mammary Neoplasms, Experimental - immunology
Mammary Neoplasms, Experimental - pathology
Medical sciences
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Peritoneal Neoplasms - immunology
Peritoneal Neoplasms - pathology
Peritoneal Neoplasms - secondary
Tumors
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Summary:Background: Breast cancer treatments are most effective when initiated early, with very poor efficacy against metastatic disease. In seeking a readily metastasizing mouse breast cancer model to facilitate the search for effective therapies, E0771 medullary adenocarcinomas implanted subcutaneously in syngeneic C57BL/6 mice were studied. Materials and Methods: Standard pathological, histological and immunological methodologies were used. Results: The aggressive estrogen receptor-positive tumor invaded locally into the peritoneal cavity in 56% of mice, as well as metastasizing to the lungs in 52% of mice. The metastasis was a spontaneous event and immunosuppression was seen (e.g. generation of lyphokine activated killer cells and allogeneic cytotoxic T lymphocytes cytolytic activities ex vivo were suppressed). Other pathological events noted as the tumor progressed were: bloody ascites (56%) and shock (72%), both attributed to local (peritoneal) tumor invasion. Conclusion: The E0771 metastatic breast cancer model, which mimics the human disease, should be useful in testing new treatments against this disease and/or in examining the metastatic process.
ISSN:0250-7005
1791-7530