4-Benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300

Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca(2+)-...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2005-12, Vol.66 (23), p.2776-2779
Main Authors: Hosoe, T, Iizuka, T, Wakana, D, Itabashi, T, Nozawa, K, Fukushima, K, Kawai, K
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
antibacterial properties
antifungal properties
Aorta, Thoracic - drug effects
Aorta, Thoracic - physiology
Benzyl Compounds - chemistry
Benzyl Compounds - isolation & purification
Benzyl Compounds - pharmacology
Biological and medical sciences
Calcium - pharmacology
Chemical constitution
chemical structure
Dose-Response Relationship, Drug
erythroglaucin
Fundamental and applied biological sciences. Psychology
furans
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
Hemoproteins
In Vitro Techniques
Magnetic Resonance Spectroscopy
Malbranchea
Malbranchea filamentosa
Male
Metalloproteins
Microbial Sensitivity Tests
Molecular Structure
Onygenales - chemistry
Plant physiology and development
Potassium - pharmacology
Proteins
Rats
Rats, Wistar
spectral analysis
Spectrometry, Mass, Electrospray Ionization
stereochemistry
vasodilator agents
Vasodilator Agents - chemistry
Vasodilator Agents - pharmacology
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Summary:Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca(2+)-induced vasocintraction in aortic rings pretreated with high K(+) (60 mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic microorganisms.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2005.08.014