Structural biology of the thioester-dependent degradation and synthesis of fatty acids

The fatty acid degradation and synthesis pathways consist of the same four chemical transformations. These transformations are facilitated by conjugating the fatty acid, via a thioester bond, to coenzyme A or acyl carrier protein in, respectively, the degradation and synthesis pathways. These pathwa...

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Bibliographic Details
Published in:Current opinion in structural biology 2005-12, Vol.15 (6), p.621-628
Main Authors: Bhaumik, Prasenjit, Koski, M Kristian, Glumoff, Tuomo, Hiltunen, J Kalervo, Wierenga, Rik K
Format: Article
Language:English
Subjects:
Acyl Carrier Protein - metabolism
Animals
Coenzyme A - metabolism
Cytosol - metabolism
Enoyl-CoA Hydratase - metabolism
Fatty Acid Synthases - metabolism
Fatty Acids - biosynthesis
Humans
Mitochondria - metabolism
Models, Molecular
Multienzyme Complexes - metabolism
Oxidation-Reduction
Peroxisomes - metabolism
Protein Conformation
Sulfhydryl Compounds - metabolism
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Summary:The fatty acid degradation and synthesis pathways consist of the same four chemical transformations. These transformations are facilitated by conjugating the fatty acid, via a thioester bond, to coenzyme A or acyl carrier protein in, respectively, the degradation and synthesis pathways. These pathways are compartmentalized in the peroxisomes, mitochondria and cytosol of eukaryotic cells. Current structural knowledge of the enzymes comprising these pathways shows that the approximately 130 entries in the RCSB Protein Data Bank can be grouped into seven superfamilies. Multifunctional enzymes are important in both pathways.
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2005.10.010