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Structural biology of the thioester-dependent degradation and synthesis of fatty acids
The fatty acid degradation and synthesis pathways consist of the same four chemical transformations. These transformations are facilitated by conjugating the fatty acid, via a thioester bond, to coenzyme A or acyl carrier protein in, respectively, the degradation and synthesis pathways. These pathwa...
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| Published in: | Current opinion in structural biology 2005-12, Vol.15 (6), p.621-628 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c351t-5e5b63b6f55d9bc3a628fc0f569ad89ef9c85d096ec40372d94b03f562a6ec353 |
| container_end_page | 628 |
| container_issue | 6 |
| container_start_page | 621 |
| container_title | Current opinion in structural biology |
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| creator | Bhaumik, Prasenjit Koski, M Kristian Glumoff, Tuomo Hiltunen, J Kalervo Wierenga, Rik K |
| description | The fatty acid degradation and synthesis pathways consist of the same four chemical transformations. These transformations are facilitated by conjugating the fatty acid, via a thioester bond, to coenzyme A or acyl carrier protein in, respectively, the degradation and synthesis pathways. These pathways are compartmentalized in the peroxisomes, mitochondria and cytosol of eukaryotic cells. Current structural knowledge of the enzymes comprising these pathways shows that the approximately 130 entries in the RCSB Protein Data Bank can be grouped into seven superfamilies. Multifunctional enzymes are important in both pathways. |
| doi_str_mv | 10.1016/j.sbi.2005.10.010 |
| format | article |
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| ispartof | Current opinion in structural biology, 2005-12, Vol.15 (6), p.621-628 |
| issn | 0959-440X 1879-033X |
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| source | Elsevier |
| subjects | Acyl Carrier Protein - metabolism Animals Coenzyme A - metabolism Cytosol - metabolism Enoyl-CoA Hydratase - metabolism Fatty Acid Synthases - metabolism Fatty Acids - biosynthesis Humans Mitochondria - metabolism Models, Molecular Multienzyme Complexes - metabolism Oxidation-Reduction Peroxisomes - metabolism Protein Conformation Sulfhydryl Compounds - metabolism |
| title | Structural biology of the thioester-dependent degradation and synthesis of fatty acids |
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