Epithelial and mucosal gamma delta T cells

Although they constitute a small part of the circulating lymphocyte population, gammadelta T cells are found in high abundance on mucosal and epithelial surfaces. These gammadelta T cells are activated in response to stress to the surrounding tissue and perform a number of functions depending upon t...

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Bibliographic Details
Published in:Current Opinion in Immunology 2006-10, Vol.18 (5), p.534-538
Main Authors: Komori, H Kiyomi, Meehan, Terrence F, Havran, Wendy L
Format: Article
Language:English
Subjects:
Animals
Epithelial Cells - immunology
Homeostasis - immunology
Humans
Infection - immunology
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Neoplasms - immunology
Receptors, Antigen, T-Cell, gamma-delta - immunology
Skin - cytology
Skin - immunology
T-Lymphocytes - immunology
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Summary:Although they constitute a small part of the circulating lymphocyte population, gammadelta T cells are found in high abundance on mucosal and epithelial surfaces. These gammadelta T cells are activated in response to stress to the surrounding tissue and perform a number of functions depending upon the location and type of stress that has occurred. Roles elucidated recently for gammadelta T cells include modulation of epithelial homeostasis through insulin-like growth factor-1 and keratinocyte growth factor, lysis of cytomegalovirus-infected cells, and recruitment of inflammatory cells to sites of tissue damage. Recent advances have provided an understanding of the development of mucosal and skin gammadelta T cells and their roles in restoring and maintaining tissue integrity.
ISSN:0952-7915
1365-2567
DOI:10.1016/j.coi.2006.06.001