Synthesis, characterization and biological activity of oxovanadium (IV) complexes with cyclic polyalcohols

Oxovanadium (IV) complexes of the cyclic polyols conduritol C (cond) and myo-inositol (inos) of stoichiometry Na 2[VO(cond) 2] · 2H 2O and Na 2[VO(inos) 2] · H 2O were obtained in aqueous alkaline solutions. They were characterized by infrared and UV–Vis spectroscopies, thermoanalytical (thermogravi...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2005-12, Vol.99 (12), p.2322-2327
Main Authors: Etcheverry, Susana B., Barrio, Daniel A., Zinczuk, Juan, Williams, Patricia A.M., Baran, Enrique J.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - drug effects
Cell Line
Cell Proliferation - drug effects
Cells in culture
Conduritol C
Cyclohexanols - chemical synthesis
Cyclohexanols - chemistry
Cyclohexanols - pharmacology
Cyclohexenes
Glucose
Inositol - chemical synthesis
Inositol - chemistry
Inositol - pharmacology
Mice
Molecular Structure
myo-Inositol
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Osteoblasts
Osteoblasts - cytology
Osteoblasts - drug effects
Osteoblasts - metabolism
Oxovanadium (IV) complexes
Rats
Spectrophotometry
Spectroscopy, Fourier Transform Infrared
Thermodynamics
Vanadates - chemical synthesis
Vanadates - chemistry
Vanadates - pharmacology
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Summary:Oxovanadium (IV) complexes of the cyclic polyols conduritol C (cond) and myo-inositol (inos) of stoichiometry Na 2[VO(cond) 2] · 2H 2O and Na 2[VO(inos) 2] · H 2O were obtained in aqueous alkaline solutions. They were characterized by infrared and UV–Vis spectroscopies, thermoanalytical (thermogravimetric and differential thermal analysis) data and magnetic susceptibility measurements. The biological activities of the complexes on the proliferation, differentiation and glucose consumption were tested on osteoblast-like cells in culture. Conduritol C and myo-inositol did not produce any effect on these parameters. Normal and tumoral cell proliferation was inhibited about (ca.40–60%) by the two oxovanadium (IV) complexes in concentrations as low as 100 μM. The complexes were also inhibitory on cell differentiation (ca. 70–80%) while they stimulate glucose consumption. Comparisons of these effects with those of the oxovanadium (IV) cation, under the same experimental conditions, were also performed.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2005.08.013