Amsterdam Acute Aneurysm Trial: Background, Design, and Methods

The objective of the Amsterdam Acute Aneurysm Trial is to study the combined outcome of conventional emergency surgery versus endovascular treatment for ruptured abdominal aortic aneurysms. The design used was a multicenter randomized clinical trial conducted in two university hospitals and one teac...

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Bibliographic Details
Published in:Vascular 2006-05, Vol.14 (3), p.130-135
Main Author: Amsterdam Acute Aneurysm Trial Collaborators
Format: Article
Language:English
Subjects:
Aortic Aneurysm, Abdominal - economics
Aortic Aneurysm, Abdominal - surgery
Aortic Rupture - economics
Aortic Rupture - surgery
Cost-Benefit Analysis
Emergencies
Ethics, Research
Humans
Minimally Invasive Surgical Procedures - methods
Patient Selection
Quality of Life
Research Design
Treatment Outcome
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Summary:The objective of the Amsterdam Acute Aneurysm Trial is to study the combined outcome of conventional emergency surgery versus endovascular treatment for ruptured abdominal aortic aneurysms. The design used was a multicenter randomized clinical trial conducted in two university hospitals and one teaching hospital in the Amsterdam region. The study included all patients with a ruptured abdominal aneurysm who were eligible for endovascular and conventional surgery. The primary end points were combined mortality and severe morbidity. The secondary end points were quality of life and cost-effectiveness. The background, design, and methods of this trial are presented, and the ethical and legal issues of this type of research are discussed.
ISSN:1708-5381
1708-539X
DOI:10.2310/6670.2006.00027