Four butenolides are novel cytotoxic compounds isolated from the marine-derived bacterium,Streptoverticillium luteoverticillatum 11014

Four known butenolides were isolated from the ethyl acetate extracts of the culture broth of the marine-derived bacterium,Streptoverticillum luteoverticillatum, by bioassay-guided fractionation. The structures were identified on the basis of spectral data. The absolute configuration of compound (1)...

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Bibliographic Details
Published in:Archives of pharmacal research 2006-08, Vol.29 (8), p.624-626
Main Authors: Li, De -Hai, Zhu, Tian -Jiao, Liu, Hong -Bing, Fang, Yu -Chun, Gu, Qian -Qun, Zhu, Wei -Ming
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
bioassays
Cell Line, Tumor
culture media
cytotoxicity
ethyl acetate
fractionation
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
Humans
leukemia
lymphoma
Magnetic Resonance Spectroscopy
Mice
spectral analysis
Stereoisomerism
Streptomyces - chemistry
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Summary:Four known butenolides were isolated from the ethyl acetate extracts of the culture broth of the marine-derived bacterium,Streptoverticillum luteoverticillatum, by bioassay-guided fractionation. The structures were identified on the basis of spectral data. The absolute configuration of compound (1) was determined by CD spectrum for the first time. Compounds1–4 showedin vitro cytotoxicity against the murine lymphoma P388 and human leukemia K562 cell lines. This is the first report on the isolation of butenolides from the marine bacterium,Streptoverticillium luteoverticillatum, and their cytotoxic activities.
ISSN:0253-6269
1976-3786
DOI:10.1007/bf02968245