Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants

Phosphate ester hydrolysis and plasmid relaxation by metalated modified adenine polymer containing carboxyl group appendages is reported. This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2006-10, Vol.16 (20), p.5364-5367
Main Authors: Gupta, Yogita, Mathur, G.N., Parvez, Masood, Verma, Sandeep
Format: Article
Language:English
Subjects:
Adenine
Adenine - chemistry
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Catalysis
Dimerization
DNA, Superhelical - chemistry
Enzymes and enzyme inhibitors
Esters - chemistry
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods
Hydrogen-Ion Concentration
Hydrolysis
Kinetics
Models, Molecular
Plasmid cleavage
Polymer
Polymers - chemical synthesis
Polymers - chemistry
Time Factors
Zinc
Zinc - chemistry
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Summary:Phosphate ester hydrolysis and plasmid relaxation by metalated modified adenine polymer containing carboxyl group appendages is reported. This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for the hydrolysis of model phosphodiester, bis( p-nitrophenyl) phosphate (bNPP), and plasmid cleavage. Observation of a bell-shaped pH- K obs profile suggested influence of pH variation over hydrolysis rate. This metalated polymer also afforded facile relaxation of pBR322 supercoiled DNA, with an interesting reusability feature intricately associated with heterogeneous catalysis.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.07.077