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Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants
Phosphate ester hydrolysis and plasmid relaxation by metalated modified adenine polymer containing carboxyl group appendages is reported. This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for...
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| Published in: | Bioorganic & medicinal chemistry letters 2006-10, Vol.16 (20), p.5364-5367 |
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| Main Authors: | , , , |
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| cites | cdi_FETCH-LOGICAL-c415t-363b60e318c7e230c101e7977f7332864dbaff93ff2b74e6a71635507279128b3 |
| container_end_page | 5367 |
| container_issue | 20 |
| container_start_page | 5364 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 16 |
| creator | Gupta, Yogita Mathur, G.N. Parvez, Masood Verma, Sandeep |
| description | Phosphate ester hydrolysis and plasmid relaxation by metalated modified adenine polymer containing carboxyl group appendages is reported.
This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for the hydrolysis of model phosphodiester, bis(
p-nitrophenyl) phosphate (bNPP), and plasmid cleavage. Observation of a bell-shaped pH-
K
obs profile suggested influence of pH variation over hydrolysis rate. This metalated polymer also afforded facile relaxation of pBR322 supercoiled DNA, with an interesting reusability feature intricately associated with heterogeneous catalysis. |
| doi_str_mv | 10.1016/j.bmcl.2006.07.077 |
| format | article |
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This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for the hydrolysis of model phosphodiester, bis(
p-nitrophenyl) phosphate (bNPP), and plasmid cleavage. Observation of a bell-shaped pH-
K
obs profile suggested influence of pH variation over hydrolysis rate. This metalated polymer also afforded facile relaxation of pBR322 supercoiled DNA, with an interesting reusability feature intricately associated with heterogeneous catalysis.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2006.07.077</identifier><identifier>PMID: 16908147</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adenine ; Adenine - chemistry ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Catalysis ; Dimerization ; DNA, Superhelical - chemistry ; Enzymes and enzyme inhibitors ; Esters - chemistry ; Fundamental and applied biological sciences. Psychology ; General aspects, investigation methods ; Hydrogen-Ion Concentration ; Hydrolysis ; Kinetics ; Models, Molecular ; Plasmid cleavage ; Polymer ; Polymers - chemical synthesis ; Polymers - chemistry ; Time Factors ; Zinc ; Zinc - chemistry</subject><ispartof>Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (20), p.5364-5367</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-363b60e318c7e230c101e7977f7332864dbaff93ff2b74e6a71635507279128b3</citedby><cites>FETCH-LOGICAL-c415t-363b60e318c7e230c101e7977f7332864dbaff93ff2b74e6a71635507279128b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18146078$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16908147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Yogita</creatorcontrib><creatorcontrib>Mathur, G.N.</creatorcontrib><creatorcontrib>Parvez, Masood</creatorcontrib><creatorcontrib>Verma, Sandeep</creatorcontrib><title>Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>Phosphate ester hydrolysis and plasmid relaxation by metalated modified adenine polymer containing carboxyl group appendages is reported.
This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for the hydrolysis of model phosphodiester, bis(
p-nitrophenyl) phosphate (bNPP), and plasmid cleavage. Observation of a bell-shaped pH-
K
obs profile suggested influence of pH variation over hydrolysis rate. This metalated polymer also afforded facile relaxation of pBR322 supercoiled DNA, with an interesting reusability feature intricately associated with heterogeneous catalysis.</description><subject>Adenine</subject><subject>Adenine - chemistry</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Catalysis</subject><subject>Dimerization</subject><subject>DNA, Superhelical - chemistry</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Esters - chemistry</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>General aspects, investigation methods</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hydrolysis</topic><topic>Kinetics</topic><topic>Models, Molecular</topic><topic>Plasmid cleavage</topic><topic>Polymer</topic><topic>Polymers - chemical synthesis</topic><topic>Polymers - chemistry</topic><topic>Time Factors</topic><topic>Zinc</topic><topic>Zinc - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Yogita</creatorcontrib><creatorcontrib>Mathur, G.N.</creatorcontrib><creatorcontrib>Parvez, Masood</creatorcontrib><creatorcontrib>Verma, Sandeep</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Yogita</au><au>Mathur, G.N.</au><au>Parvez, Masood</au><au>Verma, Sandeep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2006-10-15</date><risdate>2006</risdate><volume>16</volume><issue>20</issue><spage>5364</spage><epage>5367</epage><pages>5364-5367</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Phosphate ester hydrolysis and plasmid relaxation by metalated modified adenine polymer containing carboxyl group appendages is reported.
This report describes a novel carboxyl pendant containing adenylated polymeric template, its metalation with Zn (II), and manifestation of catalytic activity for the hydrolysis of model phosphodiester, bis(
p-nitrophenyl) phosphate (bNPP), and plasmid cleavage. Observation of a bell-shaped pH-
K
obs profile suggested influence of pH variation over hydrolysis rate. This metalated polymer also afforded facile relaxation of pBR322 supercoiled DNA, with an interesting reusability feature intricately associated with heterogeneous catalysis.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16908147</pmid><doi>10.1016/j.bmcl.2006.07.077</doi><tpages>4</tpages></addata></record> |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adenine Adenine - chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences Catalysis Dimerization DNA, Superhelical - chemistry Enzymes and enzyme inhibitors Esters - chemistry Fundamental and applied biological sciences. Psychology General aspects, investigation methods Hydrogen-Ion Concentration Hydrolysis Kinetics Models, Molecular Plasmid cleavage Polymer Polymers - chemical synthesis Polymers - chemistry Time Factors Zinc Zinc - chemistry |
| title | Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants |
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