Hantavirus cardiopulmonary syndrome: immune response and pathogenesis

Hantaviruses are emerging viruses in the Americas that cause cardiopulmonary syndrome with high lethality. The intense cellular immune response to hantavirus alters normal endothelial cell barrier functions and seems to be harmful to the host. On the other hand, the humoral immune response seems to...

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Bibliographic Details
Published in:Microbes and infection 2006-07, Vol.8 (8), p.2324-2330
Main Authors: Borges, Alessandra A., Campos, Gelse M., Moreli, Marcos L., Souza, Ricardo L.M., Aquino, Victor H., Saggioro, Fabiano P., Figueiredo, Luiz T.M.
Format: Article
Language:English
Subjects:
Antibodies, Viral - analysis
Biological and medical sciences
Cardiopulmonary syndrome
Cellular immunity
Fundamental and applied biological sciences. Psychology
Hantavirus
Hantavirus - genetics
Hantavirus - immunology
Hantavirus Pulmonary Syndrome - genetics
Hantavirus Pulmonary Syndrome - immunology
Hantavirus Pulmonary Syndrome - physiopathology
Hantavirus Pulmonary Syndrome - virology
Human leukocyte antigen
Humans
Immunity, Cellular
Interferons
Interleukins
Microbiology
Miscellaneous
Models, Biological
Neutralizing antibodies
Pathogenesis
Viremia
Virology
β3 integrin
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Summary:Hantaviruses are emerging viruses in the Americas that cause cardiopulmonary syndrome with high lethality. The intense cellular immune response to hantavirus alters normal endothelial cell barrier functions and seems to be harmful to the host. On the other hand, the humoral immune response seems to be essential for recovery from infection.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2006.04.019