Antibody response to Pneumocystis jirovecii major surface glycoprotein

We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the f...

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Bibliographic Details
Published in:Emerging infectious diseases 2006-08, Vol.12 (8), p.1231-1237
Main Authors: Daly, Kieran R, Huang, Laurence, Morris, Alison, Koch, Judy, Crothers, Kristina, Levin, Linda, Eiser, Shary, Satwah, Supriya, Zucchi, Patricia, Walzer, Peter D
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - immunology
AIDS-Related Opportunistic Infections - microbiology
Antibodies, Fungal - blood
Diagnosis
Enzyme-Linked Immunosorbent Assay
Female
Fungal Proteins - immunology
Glycoproteins
HIV Infections - complications
Humans
Male
Membrane Glycoproteins - immunology
Middle Aged
Pneumocystis carinii
Pneumocystis carinii - immunology
Pneumonia, Pneumocystis - immunology
Pneumonia, Pneumocystis - microbiology
Serodiagnosis
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Summary:We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3-4 weeks (p or =50 cells/microL and first episode of pneumocystosis were the principal host factors associated with this rise (both p
ISSN:1080-6040
DOI:10.3201/eid1708.060230