Colloidal stability of Pluronic F68-coated PLGA nanoparticles: A variety of stabilisation mechanisms

Poloxamers are a family of polypropylene oxide (PPO) and polyethylene oxide (PEO) tri-block copolymers that are usually employed in the micro- and nanoparticulate engineering for drug delivery systems. The aim of this work is to study the electrophoretic mobility ( μ e ) and colloidal stability of c...

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Bibliographic Details
Published in:Journal of colloid and interface science 2006-10, Vol.302 (2), p.522-529
Main Authors: Santander-Ortega, M.J., Jódar-Reyes, A.B., Csaba, N., Bastos-González, D., Ortega-Vinuesa, J.L.
Format: Article
Language:English
Subjects:
Adsorption
Calcium Chloride - chemistry
Chemistry
Colloidal stability
Colloidal state and disperse state
Colloids
DLVO interactions
Exact sciences and technology
General and physical chemistry
Hydration interactions
Hydrogen-Ion Concentration
Lactic Acid - chemistry
Molecular Structure
Nanoparticle
Nanoparticles - chemistry
Particle Size
Physical and chemical studies. Granulometry. Electrokinetic phenomena
PLGA
Poloxamer - chemistry
Poloxamer adsorption
Polyglycolic Acid - chemistry
Polymers - chemistry
Sodium Chloride - chemistry
Steric interactions
Surface physical chemistry
Surface Properties
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Summary:Poloxamers are a family of polypropylene oxide (PPO) and polyethylene oxide (PEO) tri-block copolymers that are usually employed in the micro- and nanoparticulate engineering for drug delivery systems. The aim of this work is to study the electrophoretic mobility ( μ e ) and colloidal stability of complexes formed by adsorbing a poloxamer (Pluronic F68) onto poly( d, l-lactic- co-glycolic acid) (PLGA) nanoparticles. A variety of stabilisation mechanisms have been observed for the Pluronic-coated PLGA nanoparticles, where DLVO interactions, solvent–polymer segment interactions and hydration forces play different roles as a function of the adsorbed amount of Pluronic. In addition, the μ e and stability data of these complexes have been compared to those obtained previously using a PLGA–Pluronic F68 blend formulation. As both the μ e and the stability data are identical between the two systems, a phase separation of both components in the PLGA–Pluronic blend formulation is suggested, being the PLGA located in the core of the particles and the Pluronic in an adsorbed shell.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2006.07.031