Colloidal stability of Pluronic F68-coated PLGA nanoparticles: A variety of stabilisation mechanisms

• Published in: Journal of colloid and interface science 2006-10, Vol.302 (2), p.522-529
• Main Authors: Santander-Ortega, M.J., Jódar-Reyes, A.B., Csaba, N., Bastos-González, D., Ortega-Vinuesa, J.L.
• Format: Article
• Language: English
• Subjects: Adsorption; Calcium Chloride - chemistry; Chemistry; Colloidal stability; Colloidal state and disperse state; Colloids; DLVO interactions; Exact sciences and technology; General and physical chemistry; Hydration interactions; Hydrogen-Ion Concentration; Lactic Acid - chemistry; Molecular Structure; Nanoparticle; Nanoparticles - chemistry; Particle Size; Physical and chemical studies. Granulometry. Electrokinetic phenomena; PLGA; Poloxamer - chemistry; Poloxamer adsorption; Polyglycolic Acid - chemistry; Polymers - chemistry; Sodium Chloride - chemistry; Steric interactions; Surface physical chemistry; Surface Properties
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2006.07.031

Poloxamers are a family of polypropylene oxide (PPO) and polyethylene oxide (PEO) tri-block copolymers that are usually employed in the micro- and nanoparticulate engineering for drug delivery systems. The aim of this work is to study the electrophoretic mobility ( μ e ) and colloidal stability of complexes formed by adsorbing a poloxamer (Pluronic F68) onto poly( d, l-lactic- co-glycolic acid) (PLGA) nanoparticles. A variety of stabilisation mechanisms have been observed for the Pluronic-coated PLGA nanoparticles, where DLVO interactions, solvent–polymer segment interactions and hydration forces play different roles as a function of the adsorbed amount of Pluronic. In addition, the μ e and stability data of these complexes have been compared to those obtained previously using a PLGA–Pluronic F68 blend formulation. As both the μ e and the stability data are identical between the two systems, a phase separation of both components in the PLGA–Pluronic blend formulation is suggested, being the PLGA located in the core of the particles and the Pluronic in an adsorbed shell.