Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients

Optimal sampling times are found for a study in which one of the primary purposes is to develop a model of the pharmacokinetics of itraconazole in patients with cystic fibrosis for both capsule and solution doses. The optimal design is expected to produce reliable estimates of population parameters...

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Bibliographic Details
Published in:Journal of pharmacokinetics and pharmacodynamics 2005-08, Vol.32 (3-4), p.521-545
Main Authors: WATERHOUSE, Timothy H, REDMANN, Stefanie, DUFFULL, Stephen B, ECCLESTON, John A
Format: Article
Language:English
Subjects:
Administration, Oral
Antifungal Agents - administration & dosage
Antifungal Agents - pharmacokinetics
Aspergillosis, Allergic Bronchopulmonary - complications
Aspergillosis, Allergic Bronchopulmonary - drug therapy
Aspergillosis, Allergic Bronchopulmonary - metabolism
Biological and medical sciences
Capsules
Cystic fibrosis
Cystic Fibrosis - complications
Cystic Fibrosis - drug therapy
Cystic Fibrosis - metabolism
Errors of metabolism
Humans
Itraconazole - administration & dosage
Itraconazole - pharmacokinetics
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
Models, Biological
Parameter estimation
Pharmaceutical Solutions
Pharmacology. Drug treatments
Sampling Studies
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Summary:Optimal sampling times are found for a study in which one of the primary purposes is to develop a model of the pharmacokinetics of itraconazole in patients with cystic fibrosis for both capsule and solution doses. The optimal design is expected to produce reliable estimates of population parameters for two different structural PK models. Data collected at these sampling times are also expected to provide the researchers with sufficient information to reasonably discriminate between the two competing structural models.
ISSN:1567-567X
1573-8744
DOI:10.1007/s10928-005-0026-2