The 'accelerator hypothesis' : relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus

The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the years 1...

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Bibliographic Details
Published in:Diabetologia 2005-12, Vol.48 (12), p.2501-2504
Main Authors: KNERR, I, WOLF, J, REINEHR, T, STACHOW, R, GRABERT, M, SCHOBER, E, RASCHER, W, HOLL, R. W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Austria - epidemiology
Biological and medical sciences
Body Height
Body Mass Index
Body Weight
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
European Continental Ancestry Group
Female
Germany - epidemiology
Humans
Infant
Infant, Newborn
Male
Medical sciences
Multivariate Analysis
Prospective Studies
Risk Factors
Time Factors
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Summary:The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the years 1990-2003 in 116 pediatric clinics throughout Germany and Austria. Patients were divided into four groups according to age (0-4.9 years, 5-9.9 years, 10-14.9 years and 15-20 years). Significantly higher standard deviation scores (SDSs) for weight and BMI at diabetes onset were found for both boys and girls in the three younger age groups (up to 14.9 years of age) compared with the reference population (p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-005-0033-2